%0 Journal Article
%A Nisar, Hasan
%A Konda, Bikash
%A Roggan, Marie Denise
%A Labonté, Frederik M
%A Arif, Maryam
%A Diegeler, Sebastian
%A Schmitz, Claudia
%A Baumstark-Khan, Christa
%A Chevalier, François
%A Hellweg, Christine E
%T Effect of Reoxygenation on Radioresistance of Chronically Hypoxic A549 Non-Small Cell Lung Cancer (NSCLC) Cells Following X-Ray and Carbon Ion Exposure.
%J International journal of molecular sciences
%V 26
%N 18
%@ 1422-0067
%C Basel
%I Molecular Diversity Preservation International
%M DZNE-2025-01128
%P 9153
%D 2025
%X Hypoxia-induced radioresistance in non-small cell lung cancer (NSCLC) hinders radiotherapy efficacy. Fractionated schedules exploit reoxygenation between fractions to reverse this resistance, but the effects of post-irradiation reoxygenation remain unclear and may depend on radiation quality. We investigated survival, cell cycle progression, cytokine secretion, and gene expression in hypoxic (1 
%K Humans
%K Carcinoma, Non-Small-Cell Lung: metabolism
%K Carcinoma, Non-Small-Cell Lung: radiotherapy
%K Carcinoma, Non-Small-Cell Lung: pathology
%K Carcinoma, Non-Small-Cell Lung: genetics
%K Lung Neoplasms: metabolism
%K Lung Neoplasms: radiotherapy
%K Lung Neoplasms: pathology
%K Lung Neoplasms: genetics
%K Radiation Tolerance: drug effects
%K X-Rays
%K A549 Cells
%K Oxygen: metabolism
%K Oxygen: pharmacology
%K Cell Survival: radiation effects
%K Carbon
%K Epithelial-Mesenchymal Transition: radiation effects
%K Cell Hypoxia: radiation effects
%K Interleukin-6: metabolism
%K Gene Expression Regulation, Neoplastic: radiation effects
%K Interleukin-8: metabolism
%K DNA double-strand breaks (Other)
%K DNA repair (Other)
%K cell cycle (Other)
%K epithelial–mesenchymal transition (Other)
%K hypoxia (Other)
%K interleukin expression (Other)
%K ionizing radiation (Other)
%K lung cancer (Other)
%K non-small cell lung cancer cells (Other)
%K radioresistance (Other)
%K reoxygenation (Other)
%K survival (Other)
%K Oxygen (NLM Chemicals)
%K Carbon (NLM Chemicals)
%K Interleukin-6 (NLM Chemicals)
%K Interleukin-8 (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:41009714
%2 pmc:PMC12470565
%R 10.3390/ijms26189153
%U https://pub.dzne.de/record/281507