TY  - JOUR
AU  - Nisar, Hasan
AU  - Konda, Bikash
AU  - Roggan, Marie Denise
AU  - Labonté, Frederik M
AU  - Arif, Maryam
AU  - Diegeler, Sebastian
AU  - Schmitz, Claudia
AU  - Baumstark-Khan, Christa
AU  - Chevalier, François
AU  - Hellweg, Christine E
TI  - Effect of Reoxygenation on Radioresistance of Chronically Hypoxic A549 Non-Small Cell Lung Cancer (NSCLC) Cells Following X-Ray and Carbon Ion Exposure.
JO  - International journal of molecular sciences
VL  - 26
IS  - 18
SN  - 1422-0067
CY  - Basel
PB  - Molecular Diversity Preservation International
M1  - DZNE-2025-01128
SP  - 9153
PY  - 2025
AB  - Hypoxia-induced radioresistance in non-small cell lung cancer (NSCLC) hinders radiotherapy efficacy. Fractionated schedules exploit reoxygenation between fractions to reverse this resistance, but the effects of post-irradiation reoxygenation remain unclear and may depend on radiation quality. We investigated survival, cell cycle progression, cytokine secretion, and gene expression in hypoxic (1 
KW  - Humans
KW  - Carcinoma, Non-Small-Cell Lung: metabolism
KW  - Carcinoma, Non-Small-Cell Lung: radiotherapy
KW  - Carcinoma, Non-Small-Cell Lung: pathology
KW  - Carcinoma, Non-Small-Cell Lung: genetics
KW  - Lung Neoplasms: metabolism
KW  - Lung Neoplasms: radiotherapy
KW  - Lung Neoplasms: pathology
KW  - Lung Neoplasms: genetics
KW  - Radiation Tolerance: drug effects
KW  - X-Rays
KW  - A549 Cells
KW  - Oxygen: metabolism
KW  - Oxygen: pharmacology
KW  - Cell Survival: radiation effects
KW  - Carbon
KW  - Epithelial-Mesenchymal Transition: radiation effects
KW  - Cell Hypoxia: radiation effects
KW  - Interleukin-6: metabolism
KW  - Gene Expression Regulation, Neoplastic: radiation effects
KW  - Interleukin-8: metabolism
KW  - DNA double-strand breaks (Other)
KW  - DNA repair (Other)
KW  - cell cycle (Other)
KW  - epithelial–mesenchymal transition (Other)
KW  - hypoxia (Other)
KW  - interleukin expression (Other)
KW  - ionizing radiation (Other)
KW  - lung cancer (Other)
KW  - non-small cell lung cancer cells (Other)
KW  - radioresistance (Other)
KW  - reoxygenation (Other)
KW  - survival (Other)
KW  - Oxygen (NLM Chemicals)
KW  - Carbon (NLM Chemicals)
KW  - Interleukin-6 (NLM Chemicals)
KW  - Interleukin-8 (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:41009714
C2  - pmc:PMC12470565
DO  - DOI:10.3390/ijms26189153
UR  - https://pub.dzne.de/record/281507
ER  -