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000281510 1001_ $$aFrisoni, Giovanni B$$b0
000281510 245__ $$aNew landscape of the diagnosis of Alzheimer's disease.
000281510 260__ $$aLondon [u.a.]$$bElsevier$$c2025
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000281510 520__ $$aAlzheimer's disease involves a drastic departure from the cognitive, functional, and behavioural trajectory of normal ageing, and is both a dreaded and highly prevalent cause of disability to individuals, and a leading source of health and social care expenditure for society. Before the advent of biomarkers, post-mortem examination was the only method available to establish a definitive diagnosis. In this first paper of the Series, we review state-of-the-art diagnostic practices and the typical patient journey in specialist settings, where clinicians engage in a differential diagnosis to establish whether Alzheimer's pathology (cerebral deposition of β-amyloid and hyperphosphorylated tau) is a contributor to cognitive impairment. Biomarkers indicating dysregulation of β-amyloid and tau homeostasis, measured with PET and cerebrospinal fluid analysis, allow a molecular-level diagnosis-a mandatory step in defining eligibility for the recently approved anti-amyloid treatments. We anticipate that easily accessible blood biomarkers, already available in some countries, will lead to a new diagnostic revolution and bring about major changes in health-care systems worldwide.
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000281510 650_7 $$2NLM Chemicals$$aBiomarkers
000281510 650_7 $$2NLM Chemicals$$aAmyloid beta-Peptides
000281510 650_7 $$2NLM Chemicals$$atau Proteins
000281510 650_2 $$2MeSH$$aHumans
000281510 650_2 $$2MeSH$$aAlzheimer Disease: diagnosis
000281510 650_2 $$2MeSH$$aAlzheimer Disease: cerebrospinal fluid
000281510 650_2 $$2MeSH$$aBiomarkers: cerebrospinal fluid
000281510 650_2 $$2MeSH$$aBiomarkers: blood
000281510 650_2 $$2MeSH$$aAmyloid beta-Peptides: metabolism
000281510 650_2 $$2MeSH$$aAmyloid beta-Peptides: cerebrospinal fluid
000281510 650_2 $$2MeSH$$atau Proteins: cerebrospinal fluid
000281510 650_2 $$2MeSH$$atau Proteins: metabolism
000281510 650_2 $$2MeSH$$aDiagnosis, Differential
000281510 650_2 $$2MeSH$$aPositron-Emission Tomography
000281510 7001_ $$aHansson, Oskar$$b1
000281510 7001_ $$aNichols, Emma$$b2
000281510 7001_ $$aGaribotto, Valentina$$b3
000281510 7001_ $$aSchindler, Suzanne E$$b4
000281510 7001_ $$avan der Flier, Wiesje M$$b5
000281510 7001_ $$0P:(DE-2719)2000032$$aJessen, Frank$$b6$$udzne
000281510 7001_ $$aVillain, Nicolas$$b7
000281510 7001_ $$aArenaza-Urquijo, Eider M$$b8
000281510 7001_ $$aCrivelli, Lucia$$b9
000281510 7001_ $$aFortea, Juan$$b10
000281510 7001_ $$aGrinberg, Lea T$$b11
000281510 7001_ $$aIsmail, Zahinoor$$b12
000281510 7001_ $$aMinoshima, Satoshi$$b13
000281510 7001_ $$aOssenkoppele, Rik$$b14
000281510 7001_ $$aZetterberg, Henrik$$b15
000281510 7001_ $$aPetersen, Ronald C$$b16
000281510 7001_ $$aDubois, Bruno$$b17
000281510 773__ $$0PERI:(DE-600)1476593-7$$a10.1016/S0140-6736(25)01294-2$$gVol. 406, no. 10510, p. 1389 - 1407$$n10510$$p1389 - 1407$$tThe lancet$$v406$$x0140-6736$$y2025
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