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000281511 037__ $$aDZNE-2025-01132
000281511 041__ $$aEnglish
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000281511 1001_ $$aFox, Nick C$$b0
000281511 245__ $$aTreatment for Alzheimer's disease.
000281511 260__ $$aLondon [u.a.]$$bElsevier$$c2025
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000281511 520__ $$aOver the last three decades, the evidence on how to best treat the cognitive and non-cognitive symptoms of patients with Alzheimer's disease has increased. Although these pharmacological and non-pharmacological strategies have significantly improved health outcomes for patients with Alzheimer's disease, many lack stringent evidence of efficacy. In this second paper of the Series, we provide practical and realistic advice on how to prioritise pharmacological and non-pharmacological strategies to ameliorate cognitive impairment and behavioural and psychological symptoms of dementia. In this clinical environment, dementia specialists are faced with the challenge of holistically integrating the much anticipated and, in some respects, controversial anti-β amyloid monoclonal antibodies. Here, we present the current approval scenario of monoclonal antibodies, our view on how they might further contribute to improve patients' quality of life, and how they could be seamlessly integrated with existing best care options.
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000281511 650_7 $$2NLM Chemicals$$aAntibodies, Monoclonal
000281511 650_7 $$2NLM Chemicals$$aAmyloid beta-Peptides
000281511 650_7 $$2NLM Chemicals$$aAntibodies, Monoclonal, Humanized
000281511 650_2 $$2MeSH$$aHumans
000281511 650_2 $$2MeSH$$aAlzheimer Disease: drug therapy
000281511 650_2 $$2MeSH$$aAlzheimer Disease: therapy
000281511 650_2 $$2MeSH$$aAntibodies, Monoclonal: therapeutic use
000281511 650_2 $$2MeSH$$aQuality of Life
000281511 650_2 $$2MeSH$$aAmyloid beta-Peptides: antagonists & inhibitors
000281511 650_2 $$2MeSH$$aAmyloid beta-Peptides: immunology
000281511 650_2 $$2MeSH$$aAntibodies, Monoclonal, Humanized: therapeutic use
000281511 7001_ $$aBelder, Christopher$$b1
000281511 7001_ $$aBallard, Clive$$b2
000281511 7001_ $$aKales, Helen C$$b3
000281511 7001_ $$aMummery, Catherine$$b4
000281511 7001_ $$aCaramelli, Paulo$$b5
000281511 7001_ $$aCiccarelli, Olga$$b6
000281511 7001_ $$aFrederiksen, Kristian S$$b7
000281511 7001_ $$aGomez-Isla, Teresa$$b8
000281511 7001_ $$aIsmail, Zahinoor$$b9
000281511 7001_ $$aPaquet, Claire$$b10
000281511 7001_ $$aPetersen, Ronald C$$b11
000281511 7001_ $$0P:(DE-2719)2812234$$aPerneczky, Robert$$b12$$udzne
000281511 7001_ $$aRobinson, Louise$$b13
000281511 7001_ $$aSayin, Ozge$$b14
000281511 7001_ $$aFrisoni, Giovanni B$$b15
000281511 773__ $$0PERI:(DE-600)1476593-7$$a10.1016/S0140-6736(25)01329-7$$gVol. 406, no. 10510, p. 1408 - 1423$$n10510$$p1408 - 1423$$tThe lancet$$v406$$x0140-6736$$y2025
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