TY  - JOUR
AU  - Fox, Nick C
AU  - Belder, Christopher
AU  - Ballard, Clive
AU  - Kales, Helen C
AU  - Mummery, Catherine
AU  - Caramelli, Paulo
AU  - Ciccarelli, Olga
AU  - Frederiksen, Kristian S
AU  - Gomez-Isla, Teresa
AU  - Ismail, Zahinoor
AU  - Paquet, Claire
AU  - Petersen, Ronald C
AU  - Perneczky, Robert
AU  - Robinson, Louise
AU  - Sayin, Ozge
AU  - Frisoni, Giovanni B
TI  - Treatment for Alzheimer's disease.
JO  - The lancet
VL  - 406
IS  - 10510
SN  - 0140-6736
CY  - London [u.a.]
PB  - Elsevier
M1  - DZNE-2025-01132
SP  - 1408 - 1423
PY  - 2025
AB  - Over the last three decades, the evidence on how to best treat the cognitive and non-cognitive symptoms of patients with Alzheimer's disease has increased. Although these pharmacological and non-pharmacological strategies have significantly improved health outcomes for patients with Alzheimer's disease, many lack stringent evidence of efficacy. In this second paper of the Series, we provide practical and realistic advice on how to prioritise pharmacological and non-pharmacological strategies to ameliorate cognitive impairment and behavioural and psychological symptoms of dementia. In this clinical environment, dementia specialists are faced with the challenge of holistically integrating the much anticipated and, in some respects, controversial anti-β amyloid monoclonal antibodies. Here, we present the current approval scenario of monoclonal antibodies, our view on how they might further contribute to improve patients' quality of life, and how they could be seamlessly integrated with existing best care options.
KW  - Humans
KW  - Alzheimer Disease: drug therapy
KW  - Alzheimer Disease: therapy
KW  - Antibodies, Monoclonal: therapeutic use
KW  - Quality of Life
KW  - Amyloid beta-Peptides: antagonists & inhibitors
KW  - Amyloid beta-Peptides: immunology
KW  - Antibodies, Monoclonal, Humanized: therapeutic use
KW  - Antibodies, Monoclonal (NLM Chemicals)
KW  - Amyloid beta-Peptides (NLM Chemicals)
KW  - Antibodies, Monoclonal, Humanized (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:40997839
DO  - DOI:10.1016/S0140-6736(25)01329-7
UR  - https://pub.dzne.de/record/281511
ER  -