%0 Journal Article
%A Albertini, Tobia
%A Dörner, Marc
%A Giannopoulos, Andreas A
%A von Känel, Roland
%A Benz, Dominik C
%A Mikail, Nidaa
%A de Wilde, Daniel
%A Voegel, Clarissa D
%A Binz, Tina M
%A Kaufmann, Philipp A
%A Gebhard, Catherine
%A Buechel, Ronny R
%A Pazhenkottil, Aju P
%T Association between inflammatory biomarkers, chronic stress, and pericoronary adipose tissue attenuation obtained with coronary CT.
%J European heart journal - cardiovascular imaging
%V 26
%N 10
%@ 2047-2404
%C Oxford
%I Oxford University Press
%M DZNE-2025-01133
%P 1664 - 1672
%D 2025
%X Pericoronary adipose tissue (PCAT) attenuation is a novel imaging biomarker of coronary inflammation associated with an increased risk of coronary artery disease (CAD). However, no studies have examined the relationship between chronic stress and PCAT. This study aimed to evaluate the intersection between chronic stress, inflammatory biomarkers, coronary plaque features, and PCAT attenuation.A total of 98 participants without known CAD were included. PCAT attenuation, total plaque volume (TPV) quantification, and vulnerable plaque features were assessed by coronary CT angiography and chronic stress was measured by hair cortisol concentration (HCC) and vital exhaustion questionnaire. Regression models were used to analyse associations of PCAT with the inflammatory biomarkers interleukin-6 (IL-6) and tumour necrosis factor-α (TNF-α), TPV, vulnerable plaque features, and coronary stenosis. Moderating analyses were performed to test whether chronic stress modulated the association between inflammatory biomarkers and PCAT attenuation. PCAT attenuation was significantly associated with IL-6 (mean difference 1.05, 95
%K Humans
%K Male
%K Female
%K Middle Aged
%K Biomarkers: blood
%K Computed Tomography Angiography: methods
%K Adipose Tissue: diagnostic imaging
%K Coronary Artery Disease: diagnostic imaging
%K Coronary Artery Disease: blood
%K Coronary Angiography: methods
%K Stress, Psychological
%K Inflammation
%K Plaque, Atherosclerotic: diagnostic imaging
%K Aged
%K Interleukin-6: blood
%K Chronic Disease
%K Tumor Necrosis Factor-alpha: blood
%K Epicardial Adipose Tissue
%K chronic stress (Other)
%K coronary artery disease (Other)
%K hair cortisol (Other)
%K interleukin-6 (Other)
%K pericoronary adipose tissue attenuation (Other)
%K vital exhaustion (Other)
%K Biomarkers (NLM Chemicals)
%K Interleukin-6 (NLM Chemicals)
%K Tumor Necrosis Factor-alpha (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40886153
%R 10.1093/ehjci/jeaf217
%U https://pub.dzne.de/record/281514