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000281514 0247_ $$2doi$$a10.1093/ehjci/jeaf217
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000281514 041__ $$aEnglish
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000281514 1001_ $$aAlbertini, Tobia$$b0
000281514 245__ $$aAssociation between inflammatory biomarkers, chronic stress, and pericoronary adipose tissue attenuation obtained with coronary CT.
000281514 260__ $$aOxford$$bOxford University Press$$c2025
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000281514 520__ $$aPericoronary adipose tissue (PCAT) attenuation is a novel imaging biomarker of coronary inflammation associated with an increased risk of coronary artery disease (CAD). However, no studies have examined the relationship between chronic stress and PCAT. This study aimed to evaluate the intersection between chronic stress, inflammatory biomarkers, coronary plaque features, and PCAT attenuation.A total of 98 participants without known CAD were included. PCAT attenuation, total plaque volume (TPV) quantification, and vulnerable plaque features were assessed by coronary CT angiography and chronic stress was measured by hair cortisol concentration (HCC) and vital exhaustion questionnaire. Regression models were used to analyse associations of PCAT with the inflammatory biomarkers interleukin-6 (IL-6) and tumour necrosis factor-α (TNF-α), TPV, vulnerable plaque features, and coronary stenosis. Moderating analyses were performed to test whether chronic stress modulated the association between inflammatory biomarkers and PCAT attenuation. PCAT attenuation was significantly associated with IL-6 (mean difference 1.05, 95% CI 0.21-1.89, P = 0.014), TNF-α (mean difference 0.60, 95% CI 0.06-1.13, P = 0.027), and a greater TPV (mean difference 3.51, 95% CI 0.02-7.00, P = 0.048), but not vulnerable plaque features or coronary stenosis. HCC (interaction term -0.12, 95% CI -0.22 to -0.02, P = 0.019) and vital exhaustion (interaction term 0.13, 95% CI 0.01-0.25, P = 0.024) moderated the relationship between IL-6, but not TNF-α, and PCAT attenuation.This study suggests that circulating inflammatory biomarkers are associated with PCAT attenuation, which was further correlated with TPV. Chronic stress may moderate the relationship between inflammatory cytokines and PCAT attenuation.
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000281514 650_7 $$2Other$$achronic stress
000281514 650_7 $$2Other$$acoronary artery disease
000281514 650_7 $$2Other$$ahair cortisol
000281514 650_7 $$2Other$$ainterleukin-6
000281514 650_7 $$2Other$$apericoronary adipose tissue attenuation
000281514 650_7 $$2Other$$avital exhaustion
000281514 650_7 $$2NLM Chemicals$$aBiomarkers
000281514 650_7 $$2NLM Chemicals$$aInterleukin-6
000281514 650_7 $$2NLM Chemicals$$aTumor Necrosis Factor-alpha
000281514 650_2 $$2MeSH$$aHumans
000281514 650_2 $$2MeSH$$aMale
000281514 650_2 $$2MeSH$$aFemale
000281514 650_2 $$2MeSH$$aMiddle Aged
000281514 650_2 $$2MeSH$$aBiomarkers: blood
000281514 650_2 $$2MeSH$$aComputed Tomography Angiography: methods
000281514 650_2 $$2MeSH$$aAdipose Tissue: diagnostic imaging
000281514 650_2 $$2MeSH$$aCoronary Artery Disease: diagnostic imaging
000281514 650_2 $$2MeSH$$aCoronary Artery Disease: blood
000281514 650_2 $$2MeSH$$aCoronary Angiography: methods
000281514 650_2 $$2MeSH$$aStress, Psychological
000281514 650_2 $$2MeSH$$aInflammation
000281514 650_2 $$2MeSH$$aPlaque, Atherosclerotic: diagnostic imaging
000281514 650_2 $$2MeSH$$aAged
000281514 650_2 $$2MeSH$$aInterleukin-6: blood
000281514 650_2 $$2MeSH$$aChronic Disease
000281514 650_2 $$2MeSH$$aTumor Necrosis Factor-alpha: blood
000281514 650_2 $$2MeSH$$aEpicardial Adipose Tissue
000281514 7001_ $$0P:(DE-2719)9002951$$aDörner, Marc$$b1$$udzne
000281514 7001_ $$aGiannopoulos, Andreas A$$b2
000281514 7001_ $$00000-0002-8929-5129$$avon Känel, Roland$$b3
000281514 7001_ $$00000-0001-8627-726X$$aBenz, Dominik C$$b4
000281514 7001_ $$aMikail, Nidaa$$b5
000281514 7001_ $$ade Wilde, Daniel$$b6
000281514 7001_ $$aVoegel, Clarissa D$$b7
000281514 7001_ $$aBinz, Tina M$$b8
000281514 7001_ $$00000-0002-9451-5210$$aKaufmann, Philipp A$$b9
000281514 7001_ $$aGebhard, Catherine$$b10
000281514 7001_ $$00000-0001-8064-8904$$aBuechel, Ronny R$$b11
000281514 7001_ $$00000-0002-8847-2154$$aPazhenkottil, Aju P$$b12
000281514 773__ $$0PERI:(DE-600)2647943-6$$a10.1093/ehjci/jeaf217$$gVol. 26, no. 10, p. 1664 - 1672$$n10$$p1664 - 1672$$tEuropean heart journal - cardiovascular imaging$$v26$$x2047-2404$$y2025
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