TY  - JOUR
AU  - Albertini, Tobia
AU  - Dörner, Marc
AU  - Giannopoulos, Andreas A
AU  - von Känel, Roland
AU  - Benz, Dominik C
AU  - Mikail, Nidaa
AU  - de Wilde, Daniel
AU  - Voegel, Clarissa D
AU  - Binz, Tina M
AU  - Kaufmann, Philipp A
AU  - Gebhard, Catherine
AU  - Buechel, Ronny R
AU  - Pazhenkottil, Aju P
TI  - Association between inflammatory biomarkers, chronic stress, and pericoronary adipose tissue attenuation obtained with coronary CT.
JO  - European heart journal - cardiovascular imaging
VL  - 26
IS  - 10
SN  - 2047-2404
CY  - Oxford
PB  - Oxford University Press
M1  - DZNE-2025-01133
SP  - 1664 - 1672
PY  - 2025
AB  - Pericoronary adipose tissue (PCAT) attenuation is a novel imaging biomarker of coronary inflammation associated with an increased risk of coronary artery disease (CAD). However, no studies have examined the relationship between chronic stress and PCAT. This study aimed to evaluate the intersection between chronic stress, inflammatory biomarkers, coronary plaque features, and PCAT attenuation.A total of 98 participants without known CAD were included. PCAT attenuation, total plaque volume (TPV) quantification, and vulnerable plaque features were assessed by coronary CT angiography and chronic stress was measured by hair cortisol concentration (HCC) and vital exhaustion questionnaire. Regression models were used to analyse associations of PCAT with the inflammatory biomarkers interleukin-6 (IL-6) and tumour necrosis factor-α (TNF-α), TPV, vulnerable plaque features, and coronary stenosis. Moderating analyses were performed to test whether chronic stress modulated the association between inflammatory biomarkers and PCAT attenuation. PCAT attenuation was significantly associated with IL-6 (mean difference 1.05, 95
KW  - Humans
KW  - Male
KW  - Female
KW  - Middle Aged
KW  - Biomarkers: blood
KW  - Computed Tomography Angiography: methods
KW  - Adipose Tissue: diagnostic imaging
KW  - Coronary Artery Disease: diagnostic imaging
KW  - Coronary Artery Disease: blood
KW  - Coronary Angiography: methods
KW  - Stress, Psychological
KW  - Inflammation
KW  - Plaque, Atherosclerotic: diagnostic imaging
KW  - Aged
KW  - Interleukin-6: blood
KW  - Chronic Disease
KW  - Tumor Necrosis Factor-alpha: blood
KW  - Epicardial Adipose Tissue
KW  - chronic stress (Other)
KW  - coronary artery disease (Other)
KW  - hair cortisol (Other)
KW  - interleukin-6 (Other)
KW  - pericoronary adipose tissue attenuation (Other)
KW  - vital exhaustion (Other)
KW  - Biomarkers (NLM Chemicals)
KW  - Interleukin-6 (NLM Chemicals)
KW  - Tumor Necrosis Factor-alpha (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:40886153
DO  - DOI:10.1093/ehjci/jeaf217
UR  - https://pub.dzne.de/record/281514
ER  -