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@ARTICLE{Albertini:281514,
      author       = {Albertini, Tobia and Dörner, Marc and Giannopoulos,
                      Andreas A and von Känel, Roland and Benz, Dominik C and
                      Mikail, Nidaa and de Wilde, Daniel and Voegel, Clarissa D
                      and Binz, Tina M and Kaufmann, Philipp A and Gebhard,
                      Catherine and Buechel, Ronny R and Pazhenkottil, Aju P},
      title        = {{A}ssociation between inflammatory biomarkers, chronic
                      stress, and pericoronary adipose tissue attenuation obtained
                      with coronary {CT}.},
      journal      = {European heart journal - cardiovascular imaging},
      volume       = {26},
      number       = {10},
      issn         = {2047-2404},
      address      = {Oxford},
      publisher    = {Oxford University Press},
      reportid     = {DZNE-2025-01133},
      pages        = {1664 - 1672},
      year         = {2025},
      abstract     = {Pericoronary adipose tissue (PCAT) attenuation is a novel
                      imaging biomarker of coronary inflammation associated with
                      an increased risk of coronary artery disease (CAD). However,
                      no studies have examined the relationship between chronic
                      stress and PCAT. This study aimed to evaluate the
                      intersection between chronic stress, inflammatory
                      biomarkers, coronary plaque features, and PCAT attenuation.A
                      total of 98 participants without known CAD were included.
                      PCAT attenuation, total plaque volume (TPV) quantification,
                      and vulnerable plaque features were assessed by coronary CT
                      angiography and chronic stress was measured by hair cortisol
                      concentration (HCC) and vital exhaustion questionnaire.
                      Regression models were used to analyse associations of PCAT
                      with the inflammatory biomarkers interleukin-6 (IL-6) and
                      tumour necrosis factor-α (TNF-α), TPV, vulnerable plaque
                      features, and coronary stenosis. Moderating analyses were
                      performed to test whether chronic stress modulated the
                      association between inflammatory biomarkers and PCAT
                      attenuation. PCAT attenuation was significantly associated
                      with IL-6 (mean difference 1.05, $95\%$ CI 0.21-1.89, P =
                      0.014), TNF-α (mean difference 0.60, $95\%$ CI 0.06-1.13, P
                      = 0.027), and a greater TPV (mean difference 3.51, $95\%$ CI
                      0.02-7.00, P = 0.048), but not vulnerable plaque features or
                      coronary stenosis. HCC (interaction term -0.12, $95\%$ CI
                      -0.22 to -0.02, P = 0.019) and vital exhaustion (interaction
                      term 0.13, $95\%$ CI 0.01-0.25, P = 0.024) moderated the
                      relationship between IL-6, but not TNF-α, and PCAT
                      attenuation.This study suggests that circulating
                      inflammatory biomarkers are associated with PCAT
                      attenuation, which was further correlated with TPV. Chronic
                      stress may moderate the relationship between inflammatory
                      cytokines and PCAT attenuation.},
      keywords     = {Humans / Male / Female / Middle Aged / Biomarkers: blood /
                      Computed Tomography Angiography: methods / Adipose Tissue:
                      diagnostic imaging / Coronary Artery Disease: diagnostic
                      imaging / Coronary Artery Disease: blood / Coronary
                      Angiography: methods / Stress, Psychological / Inflammation
                      / Plaque, Atherosclerotic: diagnostic imaging / Aged /
                      Interleukin-6: blood / Chronic Disease / Tumor Necrosis
                      Factor-alpha: blood / Epicardial Adipose Tissue / chronic
                      stress (Other) / coronary artery disease (Other) / hair
                      cortisol (Other) / interleukin-6 (Other) / pericoronary
                      adipose tissue attenuation (Other) / vital exhaustion
                      (Other) / Biomarkers (NLM Chemicals) / Interleukin-6 (NLM
                      Chemicals) / Tumor Necrosis Factor-alpha (NLM Chemicals)},
      cin          = {AG Schreiber},
      ddc          = {610},
      cid          = {I:(DE-2719)1310010},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40886153},
      doi          = {10.1093/ehjci/jeaf217},
      url          = {https://pub.dzne.de/record/281514},
}