%0 Journal Article
%A Sedghi, Annahita
%A von Rennenberg, Regina
%A Petzold, Gabor C
%A Nickenig, Georg
%A Kallmünzer, Bernd
%A Achenbach, Stephan
%A Huber, Roman
%A Seeger, Julia
%A von Sarnowski, Bettina
%A Thomalla, Goetz
%A Ringleb, Peter Arthur
%A Michalski, Dominik
%A Laufs, Ulrich
%A Royl, Georg
%A Szabo, Kristina
%A Mangner, Norman
%A Puetz, Volker
%A Kellert, Lars
%A Kaeaeb, Stefan
%A Wunderlich, Silke
%A Laugwitz, Karl-Ludwig
%A Petersen, Martina
%A Mengel, Annerose
%A Leistner, David M
%A Landmesser, Ulf
%A Endres, Matthias
%A Nolte, Christian H
%A Siepmann, Timo
%T Intravenous thrombolysis before percutaneous coronary intervention in patients with non-ST-elevation acute coronary syndrome and acute ischaemic stroke: a subanalysis of the PRAISE study.
%J Open Heart
%V 12
%N 2
%@ 2398-595X
%C London
%I BMJ
%M DZNE-2025-01135
%P e003567
%D 2025
%X In patients with acute ischaemic stroke (AIS) and concomitant non-ST-elevation acute coronary syndrome (NSTE-ACS), the role of intravenous thrombolysis (IVT) before percutaneous coronary intervention (PCI) is unclear.We performed a subanalysis of the PRAISE (PRediction of Acute coronary syndrome in acute Ischemic StrokE) study, a multicentre, prospective observational study in 247 patients with AIS and elevated high-sensitivity cardiac troponin who underwent coronary angiography based on European Society of Cardiology guidelines. The impact of IVT prior to PCI on coronary artery flow (Thrombolysis in Myocardial Infarction (TIMI) score) and myocardial perfusion (TIMI myocardial perfusion score) was compared using Fisher's exact test and logistic regression analysis, adjusting for time from stroke onset to PCI.Among 71 patients with AIS undergoing PCI, those who received IVT prior to PCI for NSTE-ACS (33 women; median age 77 (66-82 IQR)) achieved a TIMI grade 3 flow more frequently than those undergoing direct PCI (97
%K Humans
%K Female
%K Male
%K Percutaneous Coronary Intervention: adverse effects
%K Aged
%K Prospective Studies
%K Acute Coronary Syndrome: therapy
%K Acute Coronary Syndrome: complications
%K Acute Coronary Syndrome: diagnosis
%K Acute Coronary Syndrome: physiopathology
%K Thrombolytic Therapy: methods
%K Thrombolytic Therapy: adverse effects
%K Ischemic Stroke: complications
%K Ischemic Stroke: drug therapy
%K Ischemic Stroke: diagnosis
%K Aged, 80 and over
%K Fibrinolytic Agents: administration & dosage
%K Fibrinolytic Agents: adverse effects
%K Treatment Outcome
%K Coronary Angiography
%K Administration, Intravenous
%K Coronary Circulation
%K Time Factors
%K Acute Coronary Syndrome (Other)
%K Atherosclerosis (Other)
%K Percutaneous Coronary Intervention (Other)
%K Pharmacology, Clinical (Other)
%K Stroke (Other)
%K Fibrinolytic Agents (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:41022535
%R 10.1136/openhrt-2025-003567
%U https://pub.dzne.de/record/281516