TY  - JOUR
AU  - Sedghi, Annahita
AU  - von Rennenberg, Regina
AU  - Petzold, Gabor C
AU  - Nickenig, Georg
AU  - Kallmünzer, Bernd
AU  - Achenbach, Stephan
AU  - Huber, Roman
AU  - Seeger, Julia
AU  - von Sarnowski, Bettina
AU  - Thomalla, Goetz
AU  - Ringleb, Peter Arthur
AU  - Michalski, Dominik
AU  - Laufs, Ulrich
AU  - Royl, Georg
AU  - Szabo, Kristina
AU  - Mangner, Norman
AU  - Puetz, Volker
AU  - Kellert, Lars
AU  - Kaeaeb, Stefan
AU  - Wunderlich, Silke
AU  - Laugwitz, Karl-Ludwig
AU  - Petersen, Martina
AU  - Mengel, Annerose
AU  - Leistner, David M
AU  - Landmesser, Ulf
AU  - Endres, Matthias
AU  - Nolte, Christian H
AU  - Siepmann, Timo
TI  - Intravenous thrombolysis before percutaneous coronary intervention in patients with non-ST-elevation acute coronary syndrome and acute ischaemic stroke: a subanalysis of the PRAISE study.
JO  - Open Heart
VL  - 12
IS  - 2
SN  - 2398-595X
CY  - London
PB  - BMJ
M1  - DZNE-2025-01135
SP  - e003567
PY  - 2025
AB  - In patients with acute ischaemic stroke (AIS) and concomitant non-ST-elevation acute coronary syndrome (NSTE-ACS), the role of intravenous thrombolysis (IVT) before percutaneous coronary intervention (PCI) is unclear.We performed a subanalysis of the PRAISE (PRediction of Acute coronary syndrome in acute Ischemic StrokE) study, a multicentre, prospective observational study in 247 patients with AIS and elevated high-sensitivity cardiac troponin who underwent coronary angiography based on European Society of Cardiology guidelines. The impact of IVT prior to PCI on coronary artery flow (Thrombolysis in Myocardial Infarction (TIMI) score) and myocardial perfusion (TIMI myocardial perfusion score) was compared using Fisher's exact test and logistic regression analysis, adjusting for time from stroke onset to PCI.Among 71 patients with AIS undergoing PCI, those who received IVT prior to PCI for NSTE-ACS (33 women; median age 77 (66-82 IQR)) achieved a TIMI grade 3 flow more frequently than those undergoing direct PCI (97
KW  - Humans
KW  - Female
KW  - Male
KW  - Percutaneous Coronary Intervention: adverse effects
KW  - Aged
KW  - Prospective Studies
KW  - Acute Coronary Syndrome: therapy
KW  - Acute Coronary Syndrome: complications
KW  - Acute Coronary Syndrome: diagnosis
KW  - Acute Coronary Syndrome: physiopathology
KW  - Thrombolytic Therapy: methods
KW  - Thrombolytic Therapy: adverse effects
KW  - Ischemic Stroke: complications
KW  - Ischemic Stroke: drug therapy
KW  - Ischemic Stroke: diagnosis
KW  - Aged, 80 and over
KW  - Fibrinolytic Agents: administration & dosage
KW  - Fibrinolytic Agents: adverse effects
KW  - Treatment Outcome
KW  - Coronary Angiography
KW  - Administration, Intravenous
KW  - Coronary Circulation
KW  - Time Factors
KW  - Acute Coronary Syndrome (Other)
KW  - Atherosclerosis (Other)
KW  - Percutaneous Coronary Intervention (Other)
KW  - Pharmacology, Clinical (Other)
KW  - Stroke (Other)
KW  - Fibrinolytic Agents (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:41022535
DO  - DOI:10.1136/openhrt-2025-003567
UR  - https://pub.dzne.de/record/281516
ER  -