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@ARTICLE{Sedghi:281516,
      author       = {Sedghi, Annahita and von Rennenberg, Regina and Petzold,
                      Gabor C and Nickenig, Georg and Kallmünzer, Bernd and
                      Achenbach, Stephan and Huber, Roman and Seeger, Julia and
                      von Sarnowski, Bettina and Thomalla, Goetz and Ringleb,
                      Peter Arthur and Michalski, Dominik and Laufs, Ulrich and
                      Royl, Georg and Szabo, Kristina and Mangner, Norman and
                      Puetz, Volker and Kellert, Lars and Kaeaeb, Stefan and
                      Wunderlich, Silke and Laugwitz, Karl-Ludwig and Petersen,
                      Martina and Mengel, Annerose and Leistner, David M and
                      Landmesser, Ulf and Endres, Matthias and Nolte, Christian H
                      and Siepmann, Timo},
      title        = {{I}ntravenous thrombolysis before percutaneous coronary
                      intervention in patients with non-{ST}-elevation acute
                      coronary syndrome and acute ischaemic stroke: a subanalysis
                      of the {PRAISE} study.},
      journal      = {Open Heart},
      volume       = {12},
      number       = {2},
      issn         = {2398-595X},
      address      = {London},
      publisher    = {BMJ},
      reportid     = {DZNE-2025-01135},
      pages        = {e003567},
      year         = {2025},
      abstract     = {In patients with acute ischaemic stroke (AIS) and
                      concomitant non-ST-elevation acute coronary syndrome
                      (NSTE-ACS), the role of intravenous thrombolysis (IVT)
                      before percutaneous coronary intervention (PCI) is
                      unclear.We performed a subanalysis of the PRAISE (PRediction
                      of Acute coronary syndrome in acute Ischemic StrokE) study,
                      a multicentre, prospective observational study in 247
                      patients with AIS and elevated high-sensitivity cardiac
                      troponin who underwent coronary angiography based on
                      European Society of Cardiology guidelines. The impact of IVT
                      prior to PCI on coronary artery flow (Thrombolysis in
                      Myocardial Infarction (TIMI) score) and myocardial perfusion
                      (TIMI myocardial perfusion score) was compared using
                      Fisher's exact test and logistic regression analysis,
                      adjusting for time from stroke onset to PCI.Among 71
                      patients with AIS undergoing PCI, those who received IVT
                      prior to PCI for NSTE-ACS (33 women; median age 77 (66-82
                      IQR)) achieved a TIMI grade 3 flow more frequently than
                      those undergoing direct PCI $(97\%$ vs $79\%;$ p=0.04).
                      Regression analysis indicated a trend toward improved
                      coronary artery flow with IVT (adjusted OR 8.5, $95\%$ CI
                      0.9 to 75.3; p=0.05). Myocardial perfusion did not differ
                      between groups (p=0.06).This subanalysis suggests that IVT
                      before PCI may enhance coronary artery flow in selected
                      patients with NSTE-ACS with AIS. The results of this
                      exploratory subanalysis warrant further investigation,
                      particularly in patients with delayed access to PCI.},
      keywords     = {Humans / Female / Male / Percutaneous Coronary
                      Intervention: adverse effects / Aged / Prospective Studies /
                      Acute Coronary Syndrome: therapy / Acute Coronary Syndrome:
                      complications / Acute Coronary Syndrome: diagnosis / Acute
                      Coronary Syndrome: physiopathology / Thrombolytic Therapy:
                      methods / Thrombolytic Therapy: adverse effects / Ischemic
                      Stroke: complications / Ischemic Stroke: drug therapy /
                      Ischemic Stroke: diagnosis / Aged, 80 and over /
                      Fibrinolytic Agents: administration $\&$ dosage /
                      Fibrinolytic Agents: adverse effects / Treatment Outcome /
                      Coronary Angiography / Administration, Intravenous /
                      Coronary Circulation / Time Factors / Acute Coronary
                      Syndrome (Other) / Atherosclerosis (Other) / Percutaneous
                      Coronary Intervention (Other) / Pharmacology, Clinical
                      (Other) / Stroke (Other) / Fibrinolytic Agents (NLM
                      Chemicals)},
      cin          = {AG Endres},
      ddc          = {610},
      cid          = {I:(DE-2719)1811005},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41022535},
      doi          = {10.1136/openhrt-2025-003567},
      url          = {https://pub.dzne.de/record/281516},
}