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000281525 1001_ $$aBoerkoel, Aletta$$b0
000281525 245__ $$aHealth-related quality of life in patients with paediatric inflammatory bowel disease: IMPACT-III validation in Germany.
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000281525 520__ $$aHealth related quality of life (HRQoL) in paediatric patients with inflammatory bowel disease (IBD) is typically measured using the patient reported outcome measure IMPACT-III. This measure has not yet been validated for German patients using the new 4-domain structure. As Germany has a comparatively high prevalence of paediatric IBD and as the IMPACT-III is the main HRQoL outcome measure in use, a validation in the German population is overdue.To validate the main patient reported outcome measure of health-related quality of life (HRQoL) in paediatric patients with inflammatory bowel disease (IBD) IMPACT-III in a German patient sample.Clinical and HRQoL data was gathered in the CEDATA-GPGE registry. To determine the psychometric performance of the IMPACT-III in a German sample, distribution properties, reliability (Cronbach's alpha) and validity (correlations with clinical values; known-groups validity by age, sex, and self-rated health) were calculated. In addition, a confirmatory factor analysis was performed to determine the appropriateness of the factor structure.The IMPACT-III was filled out by 221 patients (Female 46%; Mage=14.05; Morbus Crohn n = 126; Ulcerative Colitis n = 79; unclassified IBD n = 18). The total score ranged from 19.29 to 95.00, without the occurrence of ceiling or floor effects. Internal consistency using Cronbach's alpha was excellent (α = 0.91) for the total scale. The total score correlated strongly with the subscales of wellbeing (r = 0.90) and social functioning (r = 0.80). Concerning validity, the subscale of wellbeing correlated with self-reported health and clinical assessments. Younger patients (< 14) reported a significantly better HRQoL than older patients (14-17). The 4-domain structure of IMPACT-III could not be confirmed through factor analysis.The German version of the IMPACT-III is a valid and reliable instrument to measure HRQoL in paediatric patients with IBD. The subscales of well-being and social functioning explain most of the total score. To interpret the subdomains of the IMPACT-III further research in a longitudinal design needs to be done, especially with age-related phrasing of the items.German Clinical Trials Register DRKS00015505. Registered on 22.01.2019 Inclusion of patients 01.03.2019; https://drks.de/search/en/trial/DRKS00015505 .
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000281525 650_7 $$2Other$$aHealth related quality of life
000281525 650_7 $$2Other$$aPaediatric inflammatory bowel diseases
000281525 650_7 $$2Other$$aPatient reported outcomes
000281525 650_7 $$2Other$$aPsychometric testing
000281525 650_2 $$2MeSH$$aHumans
000281525 650_2 $$2MeSH$$aQuality of Life: psychology
000281525 650_2 $$2MeSH$$aMale
000281525 650_2 $$2MeSH$$aFemale
000281525 650_2 $$2MeSH$$aGermany
000281525 650_2 $$2MeSH$$aAdolescent
000281525 650_2 $$2MeSH$$aPsychometrics
000281525 650_2 $$2MeSH$$aChild
000281525 650_2 $$2MeSH$$aInflammatory Bowel Diseases: psychology
000281525 650_2 $$2MeSH$$aPatient Reported Outcome Measures
000281525 650_2 $$2MeSH$$aReproducibility of Results
000281525 650_2 $$2MeSH$$aSurveys and Questionnaires: standards
000281525 7001_ $$0P:(DE-2719)9002138$$aBuchholz, Maresa$$b1$$udzne
000281525 7001_ $$aTischler, Luisa$$b2
000281525 7001_ $$0P:(DE-2719)9001915$$aWeber, Niklas$$b3$$udzne
000281525 7001_ $$0P:(DE-2719)2000040$$aHoffmann, Wolfgang$$b4$$udzne
000281525 7001_ $$ade Laffolie, Jan$$b5
000281525 7001_ $$aBerg, Neeltje van den$$b6
000281525 7001_ $$aGroup, CEDATA Study$$b7$$eCollaboration Author
000281525 773__ $$0PERI:(DE-600)2098765-1$$a10.1186/s12955-025-02437-0$$gVol. 23, no. 1, p. 94$$n1$$p94$$tHealth and quality of life outcomes$$v23$$x1477-7525$$y2025
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