TY  - JOUR
AU  - Boerkoel, Aletta
AU  - Buchholz, Maresa
AU  - Tischler, Luisa
AU  - Weber, Niklas
AU  - Hoffmann, Wolfgang
AU  - de Laffolie, Jan
AU  - Berg, Neeltje van den
TI  - Health-related quality of life in patients with paediatric inflammatory bowel disease: IMPACT-III validation in Germany.
JO  - Health and quality of life outcomes
VL  - 23
IS  - 1
SN  - 1477-7525
CY  - London
PB  - BioMed Central
M1  - DZNE-2025-01143
SP  - 94
PY  - 2025
AB  - Health related quality of life (HRQoL) in paediatric patients with inflammatory bowel disease (IBD) is typically measured using the patient reported outcome measure IMPACT-III. This measure has not yet been validated for German patients using the new 4-domain structure. As Germany has a comparatively high prevalence of paediatric IBD and as the IMPACT-III is the main HRQoL outcome measure in use, a validation in the German population is overdue.To validate the main patient reported outcome measure of health-related quality of life (HRQoL) in paediatric patients with inflammatory bowel disease (IBD) IMPACT-III in a German patient sample.Clinical and HRQoL data was gathered in the CEDATA-GPGE registry. To determine the psychometric performance of the IMPACT-III in a German sample, distribution properties, reliability (Cronbach's alpha) and validity (correlations with clinical values; known-groups validity by age, sex, and self-rated health) were calculated. In addition, a confirmatory factor analysis was performed to determine the appropriateness of the factor structure.The IMPACT-III was filled out by 221 patients (Female 46
KW  - Humans
KW  - Quality of Life: psychology
KW  - Male
KW  - Female
KW  - Germany
KW  - Adolescent
KW  - Psychometrics
KW  - Child
KW  - Inflammatory Bowel Diseases: psychology
KW  - Patient Reported Outcome Measures
KW  - Reproducibility of Results
KW  - Surveys and Questionnaires: standards
KW  - Health related quality of life (Other)
KW  - Paediatric inflammatory bowel diseases (Other)
KW  - Patient reported outcomes (Other)
KW  - Psychometric testing (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:41039592
C2  - pmc:PMC12492618
DO  - DOI:10.1186/s12955-025-02437-0
UR  - https://pub.dzne.de/record/281525
ER  -