TY  - JOUR
AU  - Hähnel, Tom
AU  - Nemitz, Anna
AU  - Schön, Katja
AU  - Berger, Luise
AU  - Vogel, Annemarie
AU  - Gruber, Doreen
AU  - Schnalke, Nils
AU  - Bräuer, Stefan
AU  - Falkenburger, Björn H
AU  - Gandor, Florin
TI  - Speech Differences between Multiple System Atrophy and Parkinson's Disease.
JO  - Movement disorders clinical practice
VL  - 12
IS  - 9
SN  - 2330-1619
CY  - New York, NY
PB  - Wiley
M1  - DZNE-2025-01150
SP  - 1391 - 1396
PY  - 2025
AB  - Delineation of Parkinson's disease (PD) from multiple system atrophy (MSA) can be challenging in early disease stages. Speech characteristics have been studied as digital biomarkers in PD and ataxias. Currently, data on speech in MSA is limited.To determine whether speech characteristics can serve as a digital biomarker to differentiate between MSA and PD.Twenty-one MSA patients and 23 PD patients underwent a battery of speech assessments: text reading, sustained phonation and diadochokinetic tasks. Speech characteristics were extracted using the software, Praat.MSA and PD speech can be described by three meaningful factors. MSA speech exhibited more reading pauses, higher pitch variability, prolonged syllables, and a more irregular speech rhythm, allowing differentiation from PD with a ROC-AUC of 0.89. Speech characteristics were correlated with motor impairment and disease severity.MSA can be differentiated from PD with good accuracy using speech analysis.
KW  - Humans
KW  - Multiple System Atrophy: complications
KW  - Multiple System Atrophy: diagnosis
KW  - Parkinson Disease: complications
KW  - Parkinson Disease: diagnosis
KW  - Female
KW  - Male
KW  - Aged
KW  - Middle Aged
KW  - Speech Disorders: etiology
KW  - Speech Disorders: diagnosis
KW  - Speech: physiology
KW  - ROC Curve
KW  - Parkinson's disease (Other)
KW  - dysarthria (Other)
KW  - multiple system atrophy (Other)
KW  - speech (Other)
KW  - voice (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:40317624
C2  - pmc:PMC12481427
DO  - DOI:10.1002/mdc3.70094
UR  - https://pub.dzne.de/record/281532
ER  -