Home > Publications Database > BBS8-dependent ciliary Hedgehog signaling governs cell fate in the white adipose tissue. > print

001     281535
005     20251111133745.0
024 7 _ |a 10.1038/s44318-025-00524-y
|2 doi
024 7 _ |a pmid:40836034
|2 pmid
024 7 _ |a pmc:PMC12489102
|2 pmc
024 7 _ |a 0261-4189
|2 ISSN
024 7 _ |a 1460-2075
|2 ISSN
037 _ _ |a DZNE-2025-01153
041 _ _ |a English
082 _ _ |a 570
100 1 _ |a Sieckmann, Katharina
|0 0009-0008-0336-8835
|b 0
245 _ _ |a BBS8-dependent ciliary Hedgehog signaling governs cell fate in the white adipose tissue.
260 _ _ |a [London]
|c 2025
|b Nature Publishing Group UK
336 7 _ |a article
|2 DRIVER
336 7 _ |a Output Types/Journal article
|2 DataCite
336 7 _ |a Journal Article
|b journal
|m journal
|0 PUB:(DE-HGF)16
|s 1762864106_6253
|2 PUB:(DE-HGF)
336 7 _ |a ARTICLE
|2 BibTeX
336 7 _ |a JOURNAL_ARTICLE
|2 ORCID
336 7 _ |a Journal Article
|0 0
|2 EndNote
520 _ _ |a The primary cilium plays a crucial role in regulating whole-body energy metabolism, as reflected in Bardet-Biedl syndrome (BBS), where ciliary dysfunction leads to obesity due to hyperphagia and white adipose tissue (WAT) remodeling. Regulation of the fate and differentiation of adipocyte precursor cells (APCs) is essential for maintaining WAT homeostasis during obesity. Using Bbs8-/- mice that recapitulate the BBS patient phenotype, we demonstrate that primary cilia dysfunction reduces the stem-cell-like P1 APC subpopulation by inducing a phenotypic switch to a fibrogenic progenitor state. This switch is characterized by extracellular matrix (ECM) remodeling and upregulation of the fibrosis marker CD9, even before the onset of obesity. Single-cell RNA sequencing reveals a direct transition of P1 APCs into fibrogenic progenitors, bypassing the committed P2 progenitor state. Ectopic ciliary Hedgehog signaling upon loss of BBS8 appears as a central driver of the molecular changes in Bbs8-/- APCs, altering their differentiation into adipocytes and promoting their lipid uptake. These findings unravel a novel role for primary cilia in governing APC fate by determining the balance between adipogenesis and fibrogenesis, and suggest potential therapeutic targets for obesity.
536 _ _ |a 354 - Disease Prevention and Healthy Aging (POF4-354)
|0 G:(DE-HGF)POF4-354
|c POF4-354
|f POF IV
|x 0
536 _ _ |a 351 - Brain Function (POF4-351)
|0 G:(DE-HGF)POF4-351
|c POF4-351
|f POF IV
|x 1
588 _ _ |a Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de
650 _ 7 |a Adipose Tissue
|2 Other
650 _ 7 |a BBS
|2 Other
650 _ 7 |a Cell Fate
|2 Other
650 _ 7 |a Cilia
|2 Other
650 _ 7 |a Hedgehog Proteins
|2 NLM Chemicals
650 _ 7 |a Microtubule-Associated Proteins
|2 NLM Chemicals
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Adipose Tissue, White: metabolism
|2 MeSH
650 _ 2 |a Adipose Tissue, White: cytology
|2 MeSH
650 _ 2 |a Adipose Tissue, White: pathology
|2 MeSH
650 _ 2 |a Mice
|2 MeSH
650 _ 2 |a Hedgehog Proteins: metabolism
|2 MeSH
650 _ 2 |a Hedgehog Proteins: genetics
|2 MeSH
650 _ 2 |a Signal Transduction
|2 MeSH
650 _ 2 |a Cilia: metabolism
|2 MeSH
650 _ 2 |a Mice, Knockout
|2 MeSH
650 _ 2 |a Cell Differentiation
|2 MeSH
650 _ 2 |a Adipogenesis
|2 MeSH
650 _ 2 |a Bardet-Biedl Syndrome: metabolism
|2 MeSH
650 _ 2 |a Bardet-Biedl Syndrome: genetics
|2 MeSH
650 _ 2 |a Bardet-Biedl Syndrome: pathology
|2 MeSH
650 _ 2 |a Obesity: metabolism
|2 MeSH
650 _ 2 |a Obesity: genetics
|2 MeSH
650 _ 2 |a Obesity: pathology
|2 MeSH
650 _ 2 |a Adipocytes: metabolism
|2 MeSH
650 _ 2 |a Adipocytes: cytology
|2 MeSH
650 _ 2 |a Microtubule-Associated Proteins: metabolism
|2 MeSH
650 _ 2 |a Microtubule-Associated Proteins: genetics
|2 MeSH
693 _ _ |0 EXP:(DE-2719)PRECISE-20190321
|5 EXP:(DE-2719)PRECISE-20190321
|e Platform for Single Cell Genomics and Epigenomics at DZNE University of Bonn
|x 0
700 1 _ |a Winnerling, Nora
|b 1
700 1 _ |a Silva Ribeiro, Dalila Juliana
|b 2
700 1 _ |a Yüksel, Seniz
|0 0000-0002-9317-9171
|b 3
700 1 _ |a Kardinal, Ronja
|0 0009-0004-3649-2024
|b 4
700 1 _ |a Steinheuer, Lisa Maria
|b 5
700 1 _ |a Frechen, Fabian
|0 0009-0003-1279-2842
|b 6
700 1 _ |a Corrêa, Luis Henrique
|b 7
700 1 _ |a Schermann, Geza
|b 8
700 1 _ |a Klausen, Christina
|b 9
700 1 _ |a Blank-Stein, Nelli
|b 10
700 1 _ |a Schulte-Schrepping, Jonas
|0 P:(DE-2719)9001500
|b 11
|u dzne
700 1 _ |a Osei-Sarpong, Collins
|0 P:(DE-2719)2813660
|b 12
700 1 _ |a Becker, Matthias
|0 P:(DE-2719)2812750
|b 13
700 1 _ |a Bonaguro, Lorenzo
|0 P:(DE-2719)9001512
|b 14
700 1 _ |a Beyer, Marc
|0 P:(DE-2719)2812219
|b 15
700 1 _ |a May-Simera, Helen Louise
|b 16
700 1 _ |a Zurkovic, Jelena
|0 0000-0002-5932-4849
|b 17
700 1 _ |a Thiele, Christoph
|0 0000-0001-5161-2558
|b 18
700 1 _ |a Thurley, Kevin
|0 0000-0002-7217-2755
|b 19
700 1 _ |a Sorokin, Lydia
|0 0000-0001-7704-7921
|b 20
700 1 _ |a Ruiz de Almodovar, Carmen
|0 0000-0001-5975-7815
|b 21
700 1 _ |a Mass, Elvira
|0 0000-0003-2318-2356
|b 22
700 1 _ |a Wachten, Dagmar
|0 P:(DE-2719)9002895
|b 23
773 _ _ |a 10.1038/s44318-025-00524-y
|g Vol. 44, no. 19, p. 5315 - 5336
|0 PERI:(DE-600)1467419-1
|n 19
|p 5315 - 5336
|t The EMBO journal
|v 44
|y 2025
|x 0261-4189
856 4 _ |u https://pub.dzne.de/record/281535/files/DZNE-2025-01153%20SUP.zip
856 4 _ |y OpenAccess
|u https://pub.dzne.de/record/281535/files/DZNE-2025-01153.pdf
856 4 _ |y OpenAccess
|x pdfa
|u https://pub.dzne.de/record/281535/files/DZNE-2025-01153.pdf?subformat=pdfa
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 11
|6 P:(DE-2719)9001500
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 12
|6 P:(DE-2719)2813660
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 13
|6 P:(DE-2719)2812750
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 14
|6 P:(DE-2719)9001512
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 15
|6 P:(DE-2719)2812219
913 1 _ |a DE-HGF
|b Gesundheit
|l Neurodegenerative Diseases
|1 G:(DE-HGF)POF4-350
|0 G:(DE-HGF)POF4-354
|3 G:(DE-HGF)POF4
|2 G:(DE-HGF)POF4-300
|4 G:(DE-HGF)POF
|v Disease Prevention and Healthy Aging
|x 0
913 1 _ |a DE-HGF
|b Gesundheit
|l Neurodegenerative Diseases
|1 G:(DE-HGF)POF4-350
|0 G:(DE-HGF)POF4-351
|3 G:(DE-HGF)POF4
|2 G:(DE-HGF)POF4-300
|4 G:(DE-HGF)POF
|v Brain Function
|x 1
914 1 _ |y 2025
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0200
|2 StatID
|b SCOPUS
|d 2024-12-30
915 _ _ |a Creative Commons Attribution CC BY (No Version)
|0 LIC:(DE-HGF)CCBYNV
|2 V:(DE-HGF)
|b DOAJ
|d 2024-04-08T07:44:01Z
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1050
|2 StatID
|b BIOSIS Previews
|d 2024-12-30
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1190
|2 StatID
|b Biological Abstracts
|d 2024-12-30
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0600
|2 StatID
|b Ebsco Academic Search
|d 2024-12-30
915 _ _ |a OpenAccess
|0 StatID:(DE-HGF)0510
|2 StatID
915 _ _ |a DEAL Wiley
|0 StatID:(DE-HGF)3001
|2 StatID
|d 2024-12-30
|w ger
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0160
|2 StatID
|b Essential Science Indicators
|d 2024-12-30
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0501
|2 StatID
|b DOAJ Seal
|d 2024-04-08T07:44:01Z
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0500
|2 StatID
|b DOAJ
|d 2024-04-08T07:44:01Z
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1030
|2 StatID
|b Current Contents - Life Sciences
|d 2024-12-30
915 _ _ |a Fees
|0 StatID:(DE-HGF)0700
|2 StatID
|d 2024-12-30
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0150
|2 StatID
|b Web of Science Core Collection
|d 2024-12-30
915 _ _ |a WoS
|0 StatID:(DE-HGF)0113
|2 StatID
|b Science Citation Index Expanded
|d 2024-12-30
915 _ _ |a Peer Review
|0 StatID:(DE-HGF)0030
|2 StatID
|b ASC
|d 2024-12-30
915 _ _ |a IF >= 10
|0 StatID:(DE-HGF)9910
|2 StatID
|b EMBO J : 2022
|d 2024-12-30
915 _ _ |a JCR
|0 StatID:(DE-HGF)0100
|2 StatID
|b EMBO J : 2022
|d 2024-12-30
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0300
|2 StatID
|b Medline
|d 2024-12-30
915 _ _ |a Article Processing Charges
|0 StatID:(DE-HGF)0561
|2 StatID
|d 2024-12-30
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0199
|2 StatID
|b Clarivate Analytics Master Journal List
|d 2024-12-30
920 1 _ |0 I:(DE-2719)1013038
|k AG Schultze
|l Clinical Single Cell Omics (CSCO) / Systems Medicine
|x 0
920 1 _ |0 I:(DE-2719)1013035
|k AG Beyer
|l Immunogenomics and Neurodegeneration
|x 1
920 1 _ |0 I:(DE-2719)5000079
|k AG Becker
|l Modular High Performance Computing and Artificial Intelligence
|x 2
920 1 _ |0 I:(DE-2719)1016005
|k AG Bonaguro
|l Molecular and Translational Immunaging
|x 3
980 _ _ |a journal
980 _ _ |a VDB
980 _ _ |a UNRESTRICTED
980 _ _ |a I:(DE-2719)1013038
980 _ _ |a I:(DE-2719)1013035
980 _ _ |a I:(DE-2719)5000079
980 _ _ |a I:(DE-2719)1016005
980 1 _ |a FullTexts

LibraryCollectionCLSMajorCLSMinorLanguageAuthor
Marc 21