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@ARTICLE{Ophey:281634,
      author       = {Ophey, Anja and Röttgen, Sinah and Doppler, Christopher E
                      J and Scharfenberg, Daniel and Kufer, Konstantin and
                      Farrher, Ezequiel and Fink, Gereon R and Sommerauer, Michael
                      and Kalbe, Elke},
      title        = {{S}ubjective cognitive decline in individuals with isolated
                      {REM} sleep behavior disorder.},
      journal      = {npj Parkinson's Disease},
      volume       = {11},
      number       = {1},
      issn         = {2373-8057},
      address      = {[London]},
      publisher    = {Springer Nature},
      reportid     = {DZNE-2025-01157},
      pages        = {287},
      year         = {2025},
      abstract     = {Subjective cognitive decline (SCD) may constitute an early
                      marker of mild cognitive impairment (MCI) in individuals
                      with isolated REM sleep behavior disorder (iRBD). In this
                      cross-sectional study, 80 individuals with iRBD were
                      classified into iRBD with MCI (RBD.MCI), with SCD
                      (RBD.SCD+), and without both (RBD.SCD-) based on
                      neuropsychological testing and the Multi-SubCoDE
                      questionnaire. The prevalence of SCD in iRBD was $36.3\%,$
                      with predominance of the amnestic multi-domain SCD profile.
                      RBD.SCD+ reported more severe depressive symptoms than
                      RBD.SCD- and showed lower cognitive performance than
                      RBD.SCD- in global cognition and attention $\&$ working
                      memory. Magnetic resonance imaging analyses revealed lower
                      grey matter volume in the left superior frontal gyrus for
                      RBD.SCD+ than RBD.SCD-, which was associated with increased
                      SCD-severity and lower global cognition. SCD without MCI in
                      iRBD is associated with subtle cognitive deficits and
                      structural brain changes. The prognostic value of SCD in
                      iRBD should be further determined in longitudinal studies.},
      cin          = {AG Wüllner / AG Petzold},
      ddc          = {610},
      cid          = {I:(DE-2719)1011302 / I:(DE-2719)1013020},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41057346},
      doi          = {10.1038/s41531-025-01161-2},
      url          = {https://pub.dzne.de/record/281634},
}