TY  - JOUR
AU  - Oertel, Frederike Cosima
AU  - Cabrera Debuc, Delia
AU  - Calabresi, Peter A
AU  - Chen, Mei
AU  - Cordano, Christian
AU  - Dietrich, Michael
AU  - Feltgen, Nicolas
AU  - Gramlich, Oliver
AU  - Green, Ari J
AU  - Groh, Janos
AU  - Huang, Su-Chun
AU  - Knier, Benjamin
AU  - Korn, Thomas
AU  - Leocani, Letizia
AU  - Loewenstein, Anat
AU  - van Oterendorp, Christian
AU  - Peto, Tunde
AU  - Schippling, Sven
AU  - Schmetterer, Leopold
AU  - Schmitz-Valckenberg, Steffen
AU  - Seeliger, Mathias W
AU  - Shindler, Kenneth S
AU  - Schuman, Joel S
AU  - Sindi, Mustafa
AU  - Tufail, Adnan
AU  - Wang, Jui-Kai
AU  - Wolf, Sebastian
AU  - You, Yuyi
AU  - Zinkernagel, Martin
AU  - Lagrèze, Wolf
AU  - Albrecht, Philipp
TI  - APOSTEL-R Recommendations for Reporting Retinal Optical Coherence Tomography Studies in Rodents.
JO  - Neurology: Neuroimmunology & Neuroinflammation ; official journal of the American Academy of Neurology
VL  - 12
IS  - 6
SN  - 2332-7812
CY  - Philadelphia, Pa.
PB  - Wolters Kluwer
M1  - DZNE-2025-01159
SP  - e200489
PY  - 2025
AB  - Retinal optical coherence tomography (OCT) in rodent models has been used to longitudinally image retinal changes, to define end points for more costly or time-consuming experiments, and to better understand the pathophysiology underlying OCT findings in human diseases. No standardization of rodent OCT reporting currently exists. Here, we aim to establish consensus recommendation for reporting results from retinal OCT studies in rodents.Initial recommendations were developed based on the APOSTEL criteria for quantitative OCT reporting in humans by a core team. Using a modified Delphi process, an expert panel of rodent OCT researchers (N = 31) and the wider scientific community discussed, refined, and voted on these initial recommendations. The list of recommendations was then revised and approved by the expert panel.The final 7-point checklist includes reporting recommendations regarding the study protocol, OCT device, acquisition settings and modifications, scanning protocol, funduscopic imaging, postacquisition data selection and image data analyses, and qualitative and quantitative results. With a median agreement score of 3 or 4 out of 4, the scientific community agreed with these recommendations. After revisions, the expert panel accepted the final recommendations.The Advised Protocol for OCT Study Terminology and Elements for reporting OCT studies in rodents (APOSTEL-R) originates from an expert consensus. They will provide guidance throughout the experimental process and will contribute to the standardization and quality improvement of preclinical OCT studies.
KW  - Tomography, Optical Coherence: standards
KW  - Tomography, Optical Coherence: methods
KW  - Animals
KW  - Retina: diagnostic imaging
KW  - Rodentia
KW  - Rats
KW  - Consensus
LB  - PUB:(DE-HGF)16
C6  - pmid:41061181
DO  - DOI:10.1212/NXI.0000000000200489
UR  - https://pub.dzne.de/record/281641
ER  -