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@ARTICLE{Oertel:281641,
author = {Oertel, Frederike Cosima and Cabrera Debuc, Delia and
Calabresi, Peter A and Chen, Mei and Cordano, Christian and
Dietrich, Michael and Feltgen, Nicolas and Gramlich, Oliver
and Green, Ari J and Groh, Janos and Huang, Su-Chun and
Knier, Benjamin and Korn, Thomas and Leocani, Letizia and
Loewenstein, Anat and van Oterendorp, Christian and Peto,
Tunde and Schippling, Sven and Schmetterer, Leopold and
Schmitz-Valckenberg, Steffen and Seeliger, Mathias W and
Shindler, Kenneth S and Schuman, Joel S and Sindi, Mustafa
and Tufail, Adnan and Wang, Jui-Kai and Wolf, Sebastian and
You, Yuyi and Zinkernagel, Martin and Lagrèze, Wolf and
Albrecht, Philipp},
collaboration = {consortium, IMSVISUAL},
title = {{APOSTEL}-{R} {R}ecommendations for {R}eporting {R}etinal
{O}ptical {C}oherence {T}omography {S}tudies in {R}odents.},
journal = {Neurology: Neuroimmunology $\&$ Neuroinflammation ;
official journal of the American Academy of Neurology},
volume = {12},
number = {6},
issn = {2332-7812},
address = {Philadelphia, Pa.},
publisher = {Wolters Kluwer},
reportid = {DZNE-2025-01159},
pages = {e200489},
year = {2025},
abstract = {Retinal optical coherence tomography (OCT) in rodent models
has been used to longitudinally image retinal changes, to
define end points for more costly or time-consuming
experiments, and to better understand the pathophysiology
underlying OCT findings in human diseases. No
standardization of rodent OCT reporting currently exists.
Here, we aim to establish consensus recommendation for
reporting results from retinal OCT studies in
rodents.Initial recommendations were developed based on the
APOSTEL criteria for quantitative OCT reporting in humans by
a core team. Using a modified Delphi process, an expert
panel of rodent OCT researchers (N = 31) and the wider
scientific community discussed, refined, and voted on these
initial recommendations. The list of recommendations was
then revised and approved by the expert panel.The final
7-point checklist includes reporting recommendations
regarding the study protocol, OCT device, acquisition
settings and modifications, scanning protocol, funduscopic
imaging, postacquisition data selection and image data
analyses, and qualitative and quantitative results. With a
median agreement score of 3 or 4 out of 4, the scientific
community agreed with these recommendations. After
revisions, the expert panel accepted the final
recommendations.The Advised Protocol for OCT Study
Terminology and Elements for reporting OCT studies in
rodents (APOSTEL-R) originates from an expert consensus.
They will provide guidance throughout the experimental
process and will contribute to the standardization and
quality improvement of preclinical OCT studies.},
keywords = {Tomography, Optical Coherence: standards / Tomography,
Optical Coherence: methods / Animals / Retina: diagnostic
imaging / Rodentia / Rats / Consensus},
cin = {AG Simons},
ddc = {610},
cid = {I:(DE-2719)1110008},
pnm = {351 - Brain Function (POF4-351)},
pid = {G:(DE-HGF)POF4-351},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:41061181},
doi = {10.1212/NXI.0000000000200489},
url = {https://pub.dzne.de/record/281641},
}