%0 Journal Article
%A Abu-Rumeileh, Samir
%A Erhart, Deborah K
%A Barba, Lorenzo
%A Konen, Franz Felix
%A Stapf, Caroline
%A Senel, Makbule
%A Hudasch, Dominica
%A Steinacker, Petra
%A Oeckl, Patrick
%A Weise, Christopher M
%A Ticozzi, Nicola
%A Halbgebauer, Steffen
%A Verde, Federico
%A Sühs, Kurt-Wolfram
%A Tumani, Hayrettin
%A Otto, Markus
%T CSF Beta-Synuclein, SNAP-25, and Neurogranin in Infectious and Autoimmune Inflammatory Neurologic Diseases.
%J Neurology: Neuroimmunology & Neuroinflammation ; official journal of the American Academy of Neurology
%V 12
%N 6
%@ 2332-7812
%C Philadelphia, Pa.
%I Wolters Kluwer
%M DZNE-2025-01160
%P e200491
%D 2025
%X Beta-synuclein (beta-syn), synaptosomal-associated protein 25 (SNAP-25), and neurogranin are CSF biomarkers of synaptic damage, which have been poorly investigated in non-neurodegenerative neurologic diseases. In this study, we examined the diagnostic and prognostic role of these markers compared with the neuroaxonal damage marker neurofilament light chain protein (NfL) in infectious and autoimmune inflammatory neurologic diseases (IINDs and AINDs).This cohort study included CSF samples from patients with different etiologies of IIND (varicella-zoster virus, herpes simplex virus, tick-borne meningoencephalitis, bacterial meningitis/(meningo)encephalitis, neuroborreliosis, or other/unknown etiology) or AIND (autoimmune encephalitis or other etiology) as well as controls.A total of 123 patients with IINDs (mean age 55.23 ± 18.04 years, 43.2
%K Humans
%K Female
%K Male
%K Middle Aged
%K Neurogranin: cerebrospinal fluid
%K Aged
%K Biomarkers: cerebrospinal fluid
%K Adult
%K Synaptosomal-Associated Protein 25: cerebrospinal fluid
%K Autoimmune Diseases of the Nervous System: cerebrospinal fluid
%K Autoimmune Diseases of the Nervous System: diagnosis
%K Cohort Studies
%K Neuroinflammatory Diseases: cerebrospinal fluid
%K Neuroinflammatory Diseases: diagnosis
%K alpha-Synuclein: cerebrospinal fluid
%K Encephalitis: cerebrospinal fluid
%K Encephalitis: diagnosis
%K Neurofilament Proteins: cerebrospinal fluid
%K Neurogranin (NLM Chemicals)
%K Biomarkers (NLM Chemicals)
%K Synaptosomal-Associated Protein 25 (NLM Chemicals)
%K SNAP25 protein, human (NLM Chemicals)
%K SNCA protein, human (NLM Chemicals)
%K alpha-Synuclein (NLM Chemicals)
%K Neurofilament Proteins (NLM Chemicals)
%K neurofilament protein L (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:41061183
%R 10.1212/NXI.0000000000200491
%U https://pub.dzne.de/record/281642