TY  - JOUR
AU  - Abu-Rumeileh, Samir
AU  - Erhart, Deborah K
AU  - Barba, Lorenzo
AU  - Konen, Franz Felix
AU  - Stapf, Caroline
AU  - Senel, Makbule
AU  - Hudasch, Dominica
AU  - Steinacker, Petra
AU  - Oeckl, Patrick
AU  - Weise, Christopher M
AU  - Ticozzi, Nicola
AU  - Halbgebauer, Steffen
AU  - Verde, Federico
AU  - Sühs, Kurt-Wolfram
AU  - Tumani, Hayrettin
AU  - Otto, Markus
TI  - CSF Beta-Synuclein, SNAP-25, and Neurogranin in Infectious and Autoimmune Inflammatory Neurologic Diseases.
JO  - Neurology: Neuroimmunology & Neuroinflammation ; official journal of the American Academy of Neurology
VL  - 12
IS  - 6
SN  - 2332-7812
CY  - Philadelphia, Pa.
PB  - Wolters Kluwer
M1  - DZNE-2025-01160
SP  - e200491
PY  - 2025
AB  - Beta-synuclein (beta-syn), synaptosomal-associated protein 25 (SNAP-25), and neurogranin are CSF biomarkers of synaptic damage, which have been poorly investigated in non-neurodegenerative neurologic diseases. In this study, we examined the diagnostic and prognostic role of these markers compared with the neuroaxonal damage marker neurofilament light chain protein (NfL) in infectious and autoimmune inflammatory neurologic diseases (IINDs and AINDs).This cohort study included CSF samples from patients with different etiologies of IIND (varicella-zoster virus, herpes simplex virus, tick-borne meningoencephalitis, bacterial meningitis/(meningo)encephalitis, neuroborreliosis, or other/unknown etiology) or AIND (autoimmune encephalitis or other etiology) as well as controls.A total of 123 patients with IINDs (mean age 55.23 ± 18.04 years, 43.2
KW  - Humans
KW  - Female
KW  - Male
KW  - Middle Aged
KW  - Neurogranin: cerebrospinal fluid
KW  - Aged
KW  - Biomarkers: cerebrospinal fluid
KW  - Adult
KW  - Synaptosomal-Associated Protein 25: cerebrospinal fluid
KW  - Autoimmune Diseases of the Nervous System: cerebrospinal fluid
KW  - Autoimmune Diseases of the Nervous System: diagnosis
KW  - Cohort Studies
KW  - Neuroinflammatory Diseases: cerebrospinal fluid
KW  - Neuroinflammatory Diseases: diagnosis
KW  - alpha-Synuclein: cerebrospinal fluid
KW  - Encephalitis: cerebrospinal fluid
KW  - Encephalitis: diagnosis
KW  - Neurofilament Proteins: cerebrospinal fluid
KW  - Neurogranin (NLM Chemicals)
KW  - Biomarkers (NLM Chemicals)
KW  - Synaptosomal-Associated Protein 25 (NLM Chemicals)
KW  - SNAP25 protein, human (NLM Chemicals)
KW  - SNCA protein, human (NLM Chemicals)
KW  - alpha-Synuclein (NLM Chemicals)
KW  - Neurofilament Proteins (NLM Chemicals)
KW  - neurofilament protein L (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:41061183
DO  - DOI:10.1212/NXI.0000000000200491
UR  - https://pub.dzne.de/record/281642
ER  -