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000281645 1001_ $$00000-0001-9105-9144$$aSchmid, Jonas$$b0
000281645 245__ $$aImmune signatures link myelin oligodendrocyte glycoprotein antibody-associated disease to other autoantibody-mediated conditions.
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000281645 520__ $$aMyelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a recently defined neurological autoimmune condition. The pathogenesis of the disease remains poorly understood, and no specific therapies are currently approved. Here, a comprehensive single-cell immunophenotyping of peripheral blood mononuclear cells from two independent cohorts of patients with MOGAD revealed pronounced immune perturbations in MOGAD when compared with healthy controls and patients with multiple sclerosis. Patients with MOGAD displayed an expansion of CXCR5-CD21- activated naïve and double-negative B cell subsets, a feature shared with patients with systemic lupus erythematosus. In addition, we observed altered Fc gamma receptor expression in natural killer cells, monocytes, and dendritic cells. Within the T cell compartment, CXCR3+CD4+ memory T cells were reduced in the circulation of patients with MOGAD compared with healthy controls, and this result was mirrored in a transgenic mouse model that showed retention of these cells in the inflamed central nervous system. Together, these results demonstrate profound systemic immune cell alterations in MOGAD and contribute to a better understanding of this distinct disease entity.
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000281645 650_7 $$2NLM Chemicals$$aMyelin-Oligodendrocyte Glycoprotein
000281645 650_7 $$2NLM Chemicals$$aAutoantibodies
000281645 650_2 $$2MeSH$$aMyelin-Oligodendrocyte Glycoprotein: immunology
000281645 650_2 $$2MeSH$$aHumans
000281645 650_2 $$2MeSH$$aAnimals
000281645 650_2 $$2MeSH$$aAutoantibodies: immunology
000281645 650_2 $$2MeSH$$aFemale
000281645 650_2 $$2MeSH$$aMice
000281645 650_2 $$2MeSH$$aMale
000281645 650_2 $$2MeSH$$aAdult
000281645 650_2 $$2MeSH$$aMiddle Aged
000281645 650_2 $$2MeSH$$aMice, Transgenic
000281645 650_2 $$2MeSH$$aLeukocytes, Mononuclear: immunology
000281645 650_2 $$2MeSH$$aImmunophenotyping
000281645 650_2 $$2MeSH$$aMyelin Oligodendrocyte Glycoprotein Antibody-Associated Disease
000281645 7001_ $$00000-0002-6857-9261$$aAlberti, Chiara$$b1
000281645 7001_ $$00000-0001-7913-931X$$aPower, Laura$$b2
000281645 7001_ $$aNuñez, Nicolás G$$b3
000281645 7001_ $$00000-0003-0121-5364$$aDe Feo, Donatella$$b4
000281645 7001_ $$00000-0002-5057-1923$$aTyystjärvi, Sofia$$b5
000281645 7001_ $$00000-0001-5236-8323$$aKulsvehagen, Laila$$b6
000281645 7001_ $$aKreiner, Victor$$b7
000281645 7001_ $$00000-0003-1657-6891$$aAyroza Bleher, Ana Beatriz$$b8
000281645 7001_ $$00009-0002-5910-7622$$aLipps, Patrick$$b9
000281645 7001_ $$00000-0003-1028-197X$$aSwinnen, Stijn$$b10
000281645 7001_ $$aIngelfinger, Florian$$b11
000281645 7001_ $$00000-0003-4406-5423$$aUlutekin, Can$$b12
000281645 7001_ $$00009-0005-0730-8133$$aChaubet, Camille$$b13
000281645 7001_ $$00000-0001-6916-7544$$aUnger, Susanne$$b14
000281645 7001_ $$00000-0001-8466-6675$$aKreutmair, Stefanie$$b15
000281645 7001_ $$aMarignier, Romain$$b16
000281645 7001_ $$00000-0002-3633-0955$$aKorn, Thomas$$b17
000281645 7001_ $$0P:(DE-2719)9003515$$aPröbstel, Anne-Katrin$$b18
000281645 7001_ $$00000-0001-5477-5475$$aLiblau, Roland$$b19
000281645 7001_ $$00000-0002-1541-7867$$aBecher, Burkhard$$b20
000281645 773__ $$0PERI:(DE-600)2518839-2$$a10.1126/scitranslmed.adw0358$$gVol. 17, no. 819, p. eadw0358$$n819$$peadw0358$$tScience translational medicine$$v17$$x1946-6234$$y2025
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