TY  - JOUR
AU  - Schmid, Jonas
AU  - Alberti, Chiara
AU  - Power, Laura
AU  - Nuñez, Nicolás G
AU  - De Feo, Donatella
AU  - Tyystjärvi, Sofia
AU  - Kulsvehagen, Laila
AU  - Kreiner, Victor
AU  - Ayroza Bleher, Ana Beatriz
AU  - Lipps, Patrick
AU  - Swinnen, Stijn
AU  - Ingelfinger, Florian
AU  - Ulutekin, Can
AU  - Chaubet, Camille
AU  - Unger, Susanne
AU  - Kreutmair, Stefanie
AU  - Marignier, Romain
AU  - Korn, Thomas
AU  - Pröbstel, Anne-Katrin
AU  - Liblau, Roland
AU  - Becher, Burkhard
TI  - Immune signatures link myelin oligodendrocyte glycoprotein antibody-associated disease to other autoantibody-mediated conditions.
JO  - Science translational medicine
VL  - 17
IS  - 819
SN  - 1946-6234
CY  - Washington, DC
PB  - AAAS
M1  - DZNE-2025-01163
SP  - eadw0358
PY  - 2025
AB  - Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a recently defined neurological autoimmune condition. The pathogenesis of the disease remains poorly understood, and no specific therapies are currently approved. Here, a comprehensive single-cell immunophenotyping of peripheral blood mononuclear cells from two independent cohorts of patients with MOGAD revealed pronounced immune perturbations in MOGAD when compared with healthy controls and patients with multiple sclerosis. Patients with MOGAD displayed an expansion of CXCR5-CD21- activated naïve and double-negative B cell subsets, a feature shared with patients with systemic lupus erythematosus. In addition, we observed altered Fc gamma receptor expression in natural killer cells, monocytes, and dendritic cells. Within the T cell compartment, CXCR3+CD4+ memory T cells were reduced in the circulation of patients with MOGAD compared with healthy controls, and this result was mirrored in a transgenic mouse model that showed retention of these cells in the inflamed central nervous system. Together, these results demonstrate profound systemic immune cell alterations in MOGAD and contribute to a better understanding of this distinct disease entity.
KW  - Myelin-Oligodendrocyte Glycoprotein: immunology
KW  - Humans
KW  - Animals
KW  - Autoantibodies: immunology
KW  - Female
KW  - Mice
KW  - Male
KW  - Adult
KW  - Middle Aged
KW  - Mice, Transgenic
KW  - Leukocytes, Mononuclear: immunology
KW  - Immunophenotyping
KW  - Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease
KW  - Myelin-Oligodendrocyte Glycoprotein (NLM Chemicals)
KW  - Autoantibodies (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:41061045
DO  - DOI:10.1126/scitranslmed.adw0358
UR  - https://pub.dzne.de/record/281645
ER  -