Home > Publications Database > Immune signatures link myelin oligodendrocyte glycoprotein antibody-associated disease to other autoantibody-mediated conditions. > print

001     281645
005     20251102002102.0
024 7 _ |a 10.1126/scitranslmed.adw0358
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024 7 _ |a pmid:41061045
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024 7 _ |a 1946-6234
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024 7 _ |a 1946-6242
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024 7 _ |a altmetric:182243566
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037 _ _ |a DZNE-2025-01163
041 _ _ |a English
082 _ _ |a 500
100 1 _ |a Schmid, Jonas
|0 0000-0001-9105-9144
|b 0
245 _ _ |a Immune signatures link myelin oligodendrocyte glycoprotein antibody-associated disease to other autoantibody-mediated conditions.
260 _ _ |a Washington, DC
|c 2025
|b AAAS
336 7 _ |a article
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336 7 _ |a ARTICLE
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336 7 _ |a JOURNAL_ARTICLE
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336 7 _ |a Journal Article
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520 _ _ |a Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a recently defined neurological autoimmune condition. The pathogenesis of the disease remains poorly understood, and no specific therapies are currently approved. Here, a comprehensive single-cell immunophenotyping of peripheral blood mononuclear cells from two independent cohorts of patients with MOGAD revealed pronounced immune perturbations in MOGAD when compared with healthy controls and patients with multiple sclerosis. Patients with MOGAD displayed an expansion of CXCR5-CD21- activated naïve and double-negative B cell subsets, a feature shared with patients with systemic lupus erythematosus. In addition, we observed altered Fc gamma receptor expression in natural killer cells, monocytes, and dendritic cells. Within the T cell compartment, CXCR3+CD4+ memory T cells were reduced in the circulation of patients with MOGAD compared with healthy controls, and this result was mirrored in a transgenic mouse model that showed retention of these cells in the inflamed central nervous system. Together, these results demonstrate profound systemic immune cell alterations in MOGAD and contribute to a better understanding of this distinct disease entity.
536 _ _ |a 353 - Clinical and Health Care Research (POF4-353)
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650 _ 7 |a Myelin-Oligodendrocyte Glycoprotein
|2 NLM Chemicals
650 _ 7 |a Autoantibodies
|2 NLM Chemicals
650 _ 2 |a Myelin-Oligodendrocyte Glycoprotein: immunology
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Autoantibodies: immunology
|2 MeSH
650 _ 2 |a Female
|2 MeSH
650 _ 2 |a Mice
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Adult
|2 MeSH
650 _ 2 |a Middle Aged
|2 MeSH
650 _ 2 |a Mice, Transgenic
|2 MeSH
650 _ 2 |a Leukocytes, Mononuclear: immunology
|2 MeSH
650 _ 2 |a Immunophenotyping
|2 MeSH
650 _ 2 |a Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease
|2 MeSH
700 1 _ |a Alberti, Chiara
|0 0000-0002-6857-9261
|b 1
700 1 _ |a Power, Laura
|0 0000-0001-7913-931X
|b 2
700 1 _ |a Nuñez, Nicolás G
|b 3
700 1 _ |a De Feo, Donatella
|0 0000-0003-0121-5364
|b 4
700 1 _ |a Tyystjärvi, Sofia
|0 0000-0002-5057-1923
|b 5
700 1 _ |a Kulsvehagen, Laila
|0 0000-0001-5236-8323
|b 6
700 1 _ |a Kreiner, Victor
|b 7
700 1 _ |a Ayroza Bleher, Ana Beatriz
|0 0000-0003-1657-6891
|b 8
700 1 _ |a Lipps, Patrick
|0 0009-0002-5910-7622
|b 9
700 1 _ |a Swinnen, Stijn
|0 0000-0003-1028-197X
|b 10
700 1 _ |a Ingelfinger, Florian
|b 11
700 1 _ |a Ulutekin, Can
|0 0000-0003-4406-5423
|b 12
700 1 _ |a Chaubet, Camille
|0 0009-0005-0730-8133
|b 13
700 1 _ |a Unger, Susanne
|0 0000-0001-6916-7544
|b 14
700 1 _ |a Kreutmair, Stefanie
|0 0000-0001-8466-6675
|b 15
700 1 _ |a Marignier, Romain
|b 16
700 1 _ |a Korn, Thomas
|0 0000-0002-3633-0955
|b 17
700 1 _ |a Pröbstel, Anne-Katrin
|0 P:(DE-2719)9003515
|b 18
700 1 _ |a Liblau, Roland
|0 0000-0001-5477-5475
|b 19
700 1 _ |a Becher, Burkhard
|0 0000-0002-1541-7867
|b 20
773 _ _ |a 10.1126/scitranslmed.adw0358
|g Vol. 17, no. 819, p. eadw0358
|0 PERI:(DE-600)2518839-2
|n 819
|p eadw0358
|t Science translational medicine
|v 17
|y 2025
|x 1946-6234
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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