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@ARTICLE{Shen:281647,
author = {Shen, Xueyi and Barbu, Miruna and Caramaschi, Doretta and
Arathimos, Ryan and Czamara, Darina and David, Friederike S
and Dearman, Anna and Dilkes, Evelyn and Herrera-Rivero,
Marisol and Huider, Floris and Kühn, Luise and Lu,
Kuan-Chen and Palviainen, Teemu and Schowe, Alicia M and
Shireby, Gemma and Weihs, Antoine and Wong, Chloe C Y and
Davyson, Eleanor and Casey, Hannah and Adams, Mark J and
Allgaier, Antje-Kathrin and Barber, Michael and Burrage, Joe
and Caspi, Avshalom and Costeira, Ricardo and Dunn, Erin C
and Feldmann, Lisa and Frank, Josef and Freisleder, Franz J
and Gadd, Danni A and Greimel, Ellen and Hannon, Eilis and
Harris, Sarah E and Homuth, Georg and Howard, David M and
Iurato, Stella and Korhonen, Tellervo and Lu, Tzu-Pin and
Martin, Nicholas G and Martins, Jade and McDermott, Edel and
Meinert, Susanne and Navarro, Pau and Ollikainen, Miina and
Pehl, Verena and Piechaczek, Charlotte and Scherff, Aline D
and Stein, Frederike and Streit, Fabian and Teumer,
Alexander and Völzke, Henry and van Dongen, Jenny and
Walker, Rosie M and Yusupov, Natan and Arseneault, Louise
and Bell, Jordana T and Berger, Klaus and Binder, Elisabeth
and Boomsma, Dorret I and Cox, Simon R and Dannlowski, Udo
and Evans, Kathryn L and Fisher, Helen L and Forstner,
Andreas J and Grabe, Hans J and Kaprio, Jaakko and Kircher,
Tilo and Kopf-Beck, Johannes and Kumari, Meena and Kuo,
Po-Hsiu and Li, Qingqin S and Moffitt, Terrie E and Mulcahy,
Hugh and Murphy, Therese M and Schulte-Körne, Gerd and
Mill, Jonathan and Lewis, Cathryn M and Wray, Naomi R and
McIntosh, Andrew M},
collaboration = {Group, PGC MDD Working},
othercontributors = {Shen, Xueyi and Caramaschi, Doretta and Arathimos, Ryan and
Czamara, Darina and David, Friederike S and Dearman, Anna
and Dilkes, Evelyn and Herrera-Rivero, Marisol and Huider,
Floris and Kühn, Luise and Lu, Kuan-Chen and Palviainen,
Teemu and Schowe, Alicia M and Shireby, Gemma and Weihs,
Antoine and Wong, Chloe C Y and Adams, Mark J and Allgaier,
Antje-Kathrin and Barber, Michael and Burrage, Joe and
Caspi, Avshalom and Costeira, Ricardo and Dunn, Erin C and
Feldmann, Lisa and Frank, Josef and Freisleder, Franz J and
Greimel, Ellen and Hannon, Eilis and Homuth, Georg and
Howard, David M and Iurato, Stella and Korhonen, Tellervo
and Lu, Tzu-Pin and Martin, Nicholas G and Martins, Jade and
McDermott, Edel and Meinert, Susanne and Ollikainen, Miina
and Pehl, Verena and Piechaczek, Charlotte and Scherff,
Aline D and Stein, Frederike and Streit, Fabian and Teumer,
Alexander and Völzke, Henry and Yusupov, Natan and
Arseneault, Louise and Bell, Jordana T and Berger, Klaus and
Binder, Elisabeth and Boomsma, Dorret I and Dannlowski, Udo
and Fisher, Helen L and Forstner, Andreas J and Grabe, Hans
and Kaprio, Jaakko and Kircher, Tilo and Kopf-Beck, Johannes
and Kumari, Meena and Kuo, Po-Hsiu and Li, Qingqin S and
Moffitt, Terrie E and Mulcahy, Hugh and Murphy, Therese M
and Schulte-Körne, Gerd and Lewis, Cathryn M and van
Dongen, Jenny and Wray, Naomi R and McIntosh, Andrew M},
title = {{A} methylome-wide association study of major depression
with out-of-sample case-control classification and
trans-ancestry comparison.},
journal = {Nature Mental Health},
volume = {3},
number = {10},
issn = {2731-6076},
address = {London},
publisher = {Nature Publishing Group UK},
reportid = {DZNE-2025-01165},
pages = {1152 - 1167},
year = {2025},
abstract = {Major depression (MD) is a leading cause of global disease
burden, and both experimental and population-based studies
suggest that differences in DNA methylation may be
associated with the condition. However, previous DNA
methylation studies have, so far, not been widely
replicated, suggesting a need for larger meta-analysis
studies. Here we conducted a meta-analysis of methylome-wide
association analysis for lifetime MD across 18 studies of
24,754 European-ancestry participants (5,443 MD cases) and
an East Asian sample (243 cases, 1,846 controls). We
identified 15 CpG sites associated with lifetime MD with
methylome-wide significance. The methylation score created
using the methylome-wide association analysis summary
statistics was significantly associated with MD status in an
out-of-sample classification analysis (area under the curve
0.53). Methylation score was also associated with five
inflammatory markers, with the strongest association found
with tumor necrosis factor beta. Mendelian randomization
analysis revealed 23 CpG sites potentially causally linked
to MD, with 7 replicated in an independent dataset. Our
study provides evidence that variations in DNA methylation
are associated with MD, and further evidence supporting
involvement of the immune system.},
keywords = {DNA methylation (Other) / Depression (Other) / Epigenomics
(Other) / Predictive markers (Other)},
cin = {AG Hoffmann / AG Grabe},
ddc = {610},
cid = {I:(DE-2719)1510600 / I:(DE-2719)5000001},
pnm = {353 - Clinical and Health Care Research (POF4-353)},
pid = {G:(DE-HGF)POF4-353},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:41069367},
pmc = {pmc:PMC12504109},
doi = {10.1038/s44220-025-00486-4},
url = {https://pub.dzne.de/record/281647},
}
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