%0 Journal Article
%A von Zedtwitz, Katharina
%A Tebartz van Elst, Ludger
%A Matteit, Isabelle
%A Schlump, Andrea
%A Lange, Thomas
%A Runge, Kimon
%A Weiser, Judith
%A Nickel, Kathrin
%A Domschke, Katharina
%A Prüss, Harald
%A Rau, Alexander
%A Reisert, Marco
%A Maier, Simon J.
%A Feige, Bernd
%A Endres, Dominique
%T Alterations in functional connectivity analyzed using MREG in patients with suspected autoimmune psychosis spectrum syndromes
%J Brain, behavior, & immunity - health
%V 49
%@ 2666-3546
%C [Amsterdam]
%I Elsevier B.V.
%M DZNE-2025-01169
%P 101111
%D 2025
%X IntroductionIn NMDA-R encephalitis, which is typically accompanied by psychotic symptoms, conventional magnetic resonance imaging (MRI) is often normal, despite widespread alterations in functional connectivity. This is the first functional connectivity study in psychiatric patients with suspected autoimmune psychosis (AP) spectrum syndromes.MethodsTwenty-eight patients with suspected AP spectrum syndromes who were selected according to the concept of autoimmune psychiatric syndromes (APS) and 28 matched healthy controls (HCs) were examined with ultrafast functional MRI using magnetic resonance encephalography (MREG). Patients were positive for either well-characterized or novel central nervous system antibodies or well-characterized systemic antibodies with autoimmune brain involvement. MREG data were processed using “Analysis of Functional NeuroImages” (AFNI) with the “Functional And Tractographic Connectivity Analysis AFNI toolbox” to analyze connectivity across 170 regions, yielding an analysis of 5995 evaluable connectivities.ResultsAfter correction for multiple testing, functional connectivity between the left middle cingulate/paracingulate gyri and the right insula (padj = 0.025) was significantly reduced in the patient group compared to HCs. Exploratory analyses revealed widespread global functional connectivity alterations in 226 of all connections (corresponding to 3.8 
%F PUB:(DE-HGF)16
%9 Journal Article
%R 10.1016/j.bbih.2025.101111
%U https://pub.dzne.de/record/281736