TY  - JOUR
AU  - von Zedtwitz, Katharina
AU  - Tebartz van Elst, Ludger
AU  - Matteit, Isabelle
AU  - Schlump, Andrea
AU  - Lange, Thomas
AU  - Runge, Kimon
AU  - Weiser, Judith
AU  - Nickel, Kathrin
AU  - Domschke, Katharina
AU  - Prüss, Harald
AU  - Rau, Alexander
AU  - Reisert, Marco
AU  - Maier, Simon J.
AU  - Feige, Bernd
AU  - Endres, Dominique
TI  - Alterations in functional connectivity analyzed using MREG in patients with suspected autoimmune psychosis spectrum syndromes
JO  - Brain, behavior, & immunity - health
VL  - 49
SN  - 2666-3546
CY  - [Amsterdam]
PB  - Elsevier B.V.
M1  - DZNE-2025-01169
SP  - 101111
PY  - 2025
AB  - IntroductionIn NMDA-R encephalitis, which is typically accompanied by psychotic symptoms, conventional magnetic resonance imaging (MRI) is often normal, despite widespread alterations in functional connectivity. This is the first functional connectivity study in psychiatric patients with suspected autoimmune psychosis (AP) spectrum syndromes.MethodsTwenty-eight patients with suspected AP spectrum syndromes who were selected according to the concept of autoimmune psychiatric syndromes (APS) and 28 matched healthy controls (HCs) were examined with ultrafast functional MRI using magnetic resonance encephalography (MREG). Patients were positive for either well-characterized or novel central nervous system antibodies or well-characterized systemic antibodies with autoimmune brain involvement. MREG data were processed using “Analysis of Functional NeuroImages” (AFNI) with the “Functional And Tractographic Connectivity Analysis AFNI toolbox” to analyze connectivity across 170 regions, yielding an analysis of 5995 evaluable connectivities.ResultsAfter correction for multiple testing, functional connectivity between the left middle cingulate/paracingulate gyri and the right insula (padj = 0.025) was significantly reduced in the patient group compared to HCs. Exploratory analyses revealed widespread global functional connectivity alterations in 226 of all connections (corresponding to 3.8 
LB  - PUB:(DE-HGF)16
DO  - DOI:10.1016/j.bbih.2025.101111
UR  - https://pub.dzne.de/record/281736
ER  -