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@ARTICLE{vonZedtwitz:281736,
      author       = {von Zedtwitz, Katharina and Tebartz van Elst, Ludger and
                      Matteit, Isabelle and Schlump, Andrea and Lange, Thomas and
                      Runge, Kimon and Weiser, Judith and Nickel, Kathrin and
                      Domschke, Katharina and Prüss, Harald and Rau, Alexander
                      and Reisert, Marco and Maier, Simon J. and Feige, Bernd and
                      Endres, Dominique},
      title        = {{A}lterations in functional connectivity analyzed using
                      {MREG} in patients with suspected autoimmune psychosis
                      spectrum syndromes},
      journal      = {Brain, behavior, $\&$ immunity - health},
      volume       = {49},
      issn         = {2666-3546},
      address      = {[Amsterdam]},
      publisher    = {Elsevier B.V.},
      reportid     = {DZNE-2025-01169},
      pages        = {101111},
      year         = {2025},
      abstract     = {IntroductionIn NMDA-R encephalitis, which is typically
                      accompanied by psychotic symptoms, conventional magnetic
                      resonance imaging (MRI) is often normal, despite widespread
                      alterations in functional connectivity. This is the first
                      functional connectivity study in psychiatric patients with
                      suspected autoimmune psychosis (AP) spectrum
                      syndromes.MethodsTwenty-eight patients with suspected AP
                      spectrum syndromes who were selected according to the
                      concept of autoimmune psychiatric syndromes (APS) and 28
                      matched healthy controls (HCs) were examined with ultrafast
                      functional MRI using magnetic resonance encephalography
                      (MREG). Patients were positive for either well-characterized
                      or novel central nervous system antibodies or
                      well-characterized systemic antibodies with autoimmune brain
                      involvement. MREG data were processed using “Analysis of
                      Functional NeuroImages” (AFNI) with the “Functional And
                      Tractographic Connectivity Analysis AFNI toolbox” to
                      analyze connectivity across 170 regions, yielding an
                      analysis of 5995 evaluable connectivities.ResultsAfter
                      correction for multiple testing, functional connectivity
                      between the left middle cingulate/paracingulate gyri and the
                      right insula (padj = 0.025) was significantly reduced in the
                      patient group compared to HCs. Exploratory analyses revealed
                      widespread global functional connectivity alterations in 226
                      of all connections (corresponding to 3.8 $\%).$ Notably, of
                      these altered connections, 99 $\%$ showed reduced
                      connectivity, while 1 $\%$ showed hyperconnectivity. The
                      medial pulvinar of the left thalamus emerged as the most
                      disconnected hub with altered connectivity to 33 other
                      regions. Overall, 46 $\%$ of all analyzed regions exhibited
                      at least one altered functional connectivity, with 19 $\%$
                      of hubs located in the cerebellum, 11 $\%$ in the frontal
                      brain, and 9 $\%$ in the thalami. After correction for
                      multiple comparisons, increased connectivity between the
                      left insula and the left superior temporal gyrus correlated
                      with the Beck Depression Inventory scores (padj =
                      0.043).DiscussionPatients with suspected AP spectrum
                      syndromes exhibit altered insular functional connectivity
                      associated with the severity of depressive symptoms. Broader
                      changes identified via hypothesis-generating analyses
                      highlighted major hubs in the cerebellum, frontal brain, and
                      thalamus. These findings suggest that functional MRI may
                      serve as an additional tool for detecting patients with
                      AP/APS. Future studies in more homogeneous
                      autoimmune-mediated patient groups may help delineate
                      specific connectivity signatures in functional networks.},
      cin          = {AG Prüß},
      ddc          = {610},
      cid          = {I:(DE-2719)1810003},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      doi          = {10.1016/j.bbih.2025.101111},
      url          = {https://pub.dzne.de/record/281736},
}