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@ARTICLE{peh:281738,
      author       = {Špeh, Andreja and Boada, Merce and Jessen, Frank and
                      Visser, Pieter Jelle and Winblad, Bengt and Wimo, Anders and
                      Sannemann, Lena and Stopar, Nina and Zwan, Marisa and
                      Rodriguez-Gomez, Octavio and Johansson, Gunilla and Alegret,
                      Montse and Rodríguez, Isabel and Gurrutxaga, Miren and
                      Sotolongo, Oscar and Ruiz, Agustin and Cantero-Fortiz,
                      Yahveth and Kramberger, Milica Gregorič},
      title        = {{C}ardiovascular health and cognition in older adults:
                      {V}ariations across recruitment models and {E}uropean
                      countries in the {MOPEAD} project.},
      journal      = {Journal of Alzheimer's disease},
      volume       = {107},
      number       = {4},
      issn         = {1387-2877},
      address      = {Amsterdam},
      publisher    = {IOS Press},
      reportid     = {DZNE-2025-01171},
      pages        = {1530 - 1538},
      year         = {2025},
      abstract     = {BackgroundThe Models of Patient Engagement for Alzheimer's
                      Disease (MOPEAD) project aimed to identify the most
                      effective and cost-efficient recruitment model for detecting
                      prodromal and mild Alzheimer's disease (AD) across five
                      European countries.ObjectiveTo examine differences in
                      cardiovascular risk factors and cognitive performance among
                      countries and recruitment models using MOPEAD
                      data.MethodsIndividuals aged 65-85 with a high risk for
                      prodromal or mild AD were included. Four recruitment models
                      were used: a web-based screening tool, an open house
                      initiative (OHI), a primary care-based protocol for early
                      detection of cognitive decline, and a tertiary care-based
                      screening at a diabetologist clinic. Participants from
                      Germany, Spain, the Netherlands, Sweden, and Slovenia were
                      recruited. Cardiovascular risk factors were self-reported,
                      and cognition was assessed using The Repeatable Battery for
                      the Assessment of Neuropsychological Status (RBANS).ResultsA
                      total of 414 individuals (mean age 71.9, SD = 5.0) were
                      included. Significant differences were observed in physical
                      activity (p < 0.001), with individuals from Sweden and
                      Slovenia being the most active. Dutch participants scored
                      highest on most cognitive measures. Individuals recruited
                      via web-based survey were youngest, most active $(61.7\%),$
                      and had the lowest rates of diabetes $(12.0\%)$ and heart
                      disease $(6.4\%),$ as well as the best cognitive scores.
                      Those recruited via diabetologist clinics displayed the
                      highest cardiovascular risk and the lowest cognitive
                      performance.ConclusionsThis study unveils significant
                      disparities in cardiovascular health and cognition across
                      recruitment strategies and European countries. The OHI shows
                      promise for future recruitment in the context of
                      disease-modifying AD treatments.},
      keywords     = {Alzheimer's disease (Other) / cardiovascular health (Other)
                      / cognition (Other) / cross-country (Other) / early
                      diagnosis (Other) / participants recruitment (Other)},
      cin          = {AG Jessen},
      ddc          = {610},
      cid          = {I:(DE-2719)1011102},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40899930},
      doi          = {10.1177/13872877251371729},
      url          = {https://pub.dzne.de/record/281738},
}