TY  - JOUR
AU  - Rohmann, Jessica L
AU  - Piccininni, Marco
AU  - Ebinger, Martin
AU  - Wendt, Matthias
AU  - Weber, Joachim E
AU  - Schwabauer, Eugen
AU  - Freitag, Erik
AU  - Zuber, Martina
AU  - Bernhardt, Lydia
AU  - Lange, Julia
AU  - Erdur, Hebun
AU  - Behrens, Janina
AU  - Ganeshan, Ramanan
AU  - Schlemm, Ludwig
AU  - Harmel, Peter
AU  - Liman, Thomas G.
AU  - Lorenz-Meyer, Irina
AU  - Rohrpasser-Napierkowski, Ira
AU  - Hille, Annegret
AU  - Bohner, Georg
AU  - Nabavi, Darius G
AU  - Schmehl, Ingo
AU  - Ekkernkamp, Axel
AU  - Jungehulsing, Gerhard J
AU  - Mackert, Bruno-Marcel
AU  - Hartmann, Andreas
AU  - Endres, Matthias
AU  - Audebert, Heinrich J
TI  - Effect of Mobile Stroke Unit Dispatch on Process Parameters and Functional Outcomes in Patients With Acute Stroke: The B_PROUD-2.0 Study.
JO  - Neurology
VL  - 105
IS  - 9
SN  - 0028-3878
CY  - Philadelphia, Pa.
PB  - Wolters Kluwer
M1  - DZNE-2025-01182
SP  - e214225
PY  - 2025
AB  - Prehospital stroke management on mobile stroke units (MSUs) shortens time to IV thrombolysis (IVT) and improves functional outcomes. Because IVT effects are time-dependent, optimizing workflows and dispatch-related processes may enhance MSU benefits. The B_PROUD-2.0 study aimed to determine the effect of additional MSU dispatch on functional outcomes in acute stroke patients under optimized MSU organization and service delivery.In the nonrandomized, controlled B_PROUD-2.0 study (May 2019-April 2021) conducted in Berlin, Germany, MSUs were simultaneously dispatched with conventional care ambulances for suspected stroke emergency calls, whenever available. We compared outcomes and process parameters between dispatch groups (additional MSU dispatch vs conventional care only) among patients with cerebral ischemia with disabling neurologic symptoms and no contraindications to reperfusion treatments. We used data from the Berlin dispatch center and records from the B_SPATIAL registry, consisting of 15 Berlin hospitals with stroke units. We performed pooled analyses with the B_PROUD-1.0 primary population (February 2017-April 2021) and with an extended cohort that also included patients with reperfusion treatment contraindications. The primary and co-primary outcomes were 3-month modified Rankin Scale scores (0: no deficits to 6: death) and 3-tiered disability scale scores. Effect estimates for these outcomes were obtained from ordinal logistic regressions, adjusting for a priori selected covariates after multiple imputation for missing values.Coronavirus disease 2019 pandemic and limited funding hindered full implementation of procedural improvements. A total of 1,050 patients (mean age: 74 years, 46.7
KW  - Humans
KW  - Female
KW  - Male
KW  - Aged
KW  - Mobile Health Units
KW  - Stroke: therapy
KW  - Thrombolytic Therapy
KW  - Middle Aged
KW  - Aged, 80 and over
KW  - Emergency Medical Services: methods
KW  - Ambulances
KW  - Time-to-Treatment
KW  - Registries
KW  - Treatment Outcome
KW  - Emergency Medical Dispatch
KW  - Berlin
KW  - COVID-19
LB  - PUB:(DE-HGF)16
C6  - pmid:41100781
DO  - DOI:10.1212/WNL.0000000000214225
UR  - https://pub.dzne.de/record/281789
ER  -