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@ARTICLE{Endres:281801,
      author       = {Endres, Dominique and Matteit, Isabelle and von Zedtwitz,
                      Katharina and Feige, Bernd and Schlump, Andrea and Reisert,
                      Marco and Nickel, Kathrin and Runge, Kimon and Domschke,
                      Katharina and Perlov, Evgeniy and Rau, Alexander and Prüss,
                      Harald and Lange, Thomas and Tebartz van Elst, Ludger and
                      Maier, Simon J},
      title        = {{MR} spectroscopic imaging and its association with {EEG},
                      {CSF}, and psychometric/neuropsychological findings in
                      patients with suspected autoimmune psychosis spectrum
                      syndromes.},
      journal      = {Acta neuropsychiatrica},
      volume       = {37},
      issn         = {0924-2708},
      address      = {Cambridge},
      publisher    = {Cambridge Univ. Press},
      reportid     = {DZNE-2025-01187},
      pages        = {e88},
      year         = {2025},
      abstract     = {Autoimmune psychosis (AP) and other autoimmune psychiatric
                      syndromes (APS) are associated with central nervous system
                      antibodies. This study investigated related magnetic
                      resonance spectroscopic imaging (MRSI) signatures and their
                      correlations with electroencephalography (EEG),
                      cerebrospinal fluid (CSF), and
                      psychometric/neuropsychological measures.Twenty-eight adults
                      with suspected antibody-positive AP spectrum syndromes were
                      compared with 28 matched healthy controls. Inclusion in the
                      patient group was based on the APS concept, resulting in a
                      heterogeneous group with uniform autoimmunity. MRSI was
                      performed using a spiral-encoded Mescher-Garwood localized
                      adiabatic selective refocusing 3D-MRSI sequence.
                      Glutamate+glutamine (Glx), gamma-aminobutyric acid (GABA),
                      total N-acetylaspartate (tNAA), and total creatine (tCr)
                      were reported as ratios to tNAA and/or tCr. EEG was analyzed
                      for intermittent rhythmic delta/theta activity (IRDA/IRTA)
                      using independent component analysis.No significant
                      differences in Glx, GABA, tNAA, or tCr ratios were observed
                      between patients and controls. Correlation analyses in
                      patients showed a trend for a negative association of the
                      IRDA/IRTA rate before hyperventilation with the GABA/tCr
                      ratio in both hippocampi and with the GABA/tNAA ratio in the
                      left hippocampus and Glx/tCr ratio in the right putamen and
                      pallidum. Significant positive correlations were observed
                      between inflammatory CSF markers (white blood cell count and
                      IgG Index) and GABA/tCr and GABA/tNAA ratios in the left
                      caudate nucleus and right isthmus cingulate and thalamus, as
                      well as between negative symptoms in PANSS and higher
                      GABA/tCr ratios in the right putamen.No group differences
                      were identified; however, correlations suggest a link
                      between neuroinflammatory CSF markers and negative symptoms
                      with GABAergic signaling in patients. Multimodal diagnostic
                      approaches may provide a better understanding of the link
                      between neuroinflammation, neurochemistry, and EEG slowing.},
      keywords     = {Autoantibody (Other) / MRS (Other) / brain (Other) /
                      neurochemistry (Other) / neuroinflammation (Other)},
      cin          = {AG Prüß},
      ddc          = {610},
      cid          = {I:(DE-2719)1810003},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40958469},
      doi          = {10.1017/neu.2025.10036},
      url          = {https://pub.dzne.de/record/281801},
}