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000281814 1001_ $$aFeringa, Femke M$$b0
000281814 245__ $$aThe Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases.
000281814 260__ $$a[London]$$bSpringer Nature$$c2025
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000281814 520__ $$aLipid alterations in the brain have been implicated in many neurodegenerative diseases. To facilitate comparative lipidomic research across brain diseases, we establish a data common named the Neurolipid Atlas that we prepopulated with isogenic induced pluripotent stem cell (iPS cell)-derived lipidomics data for different brain diseases. Additionally, the resource contains lipidomics data of human and mouse brain tissue. Leveraging multiple datasets, we demonstrate that iPS cell-derived neurons, microglia and astrocytes exhibit distinct lipid profiles that recapitulate in vivo lipotypes. Notably, the Alzheimer disease (AD) risk gene ApoE4 drives cholesterol ester (CE) accumulation specifically in human astrocytes and we also observe CE accumulation in whole-brain lipidomics from persons with AD. Multiomics interrogation of iPS cell-derived astrocytes revealed that altered cholesterol metabolism has a major role in astrocyte immune pathways such as the immunoproteasome and major histocompatibility complex class I antigen presentation. Our data commons, available online ( https://neurolipidatlas.com/ ), allows for data deposition by the community and provides a user-friendly tool and knowledge base for a better understanding of lipid dyshomeostasis in neurodegenerative diseases.
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000281814 650_2 $$2MeSH$$aHumans
000281814 650_2 $$2MeSH$$aLipidomics: methods
000281814 650_2 $$2MeSH$$aNeurodegenerative Diseases: metabolism
000281814 650_2 $$2MeSH$$aAnimals
000281814 650_2 $$2MeSH$$aMice
000281814 650_2 $$2MeSH$$aAstrocytes: metabolism
000281814 650_2 $$2MeSH$$aLipid Metabolism
000281814 650_2 $$2MeSH$$aInduced Pluripotent Stem Cells: metabolism
000281814 650_2 $$2MeSH$$aBrain: metabolism
000281814 650_2 $$2MeSH$$aNeurons: metabolism
000281814 650_2 $$2MeSH$$aAlzheimer Disease: metabolism
000281814 650_2 $$2MeSH$$aMicroglia: metabolism
000281814 7001_ $$00000-0002-7372-8946$$aKoppes-den Hertog, Sascha J$$b1
000281814 7001_ $$00009-0006-0509-6680$$aWang, Lian Y$$b2
000281814 7001_ $$00000-0002-8920-7133$$aDerks, Rico J E$$b3
000281814 7001_ $$aKruijff, Iris$$b4
000281814 7001_ $$0P:(DE-2719)9000542$$aErlebach, Lena$$b5$$udzne
000281814 7001_ $$aHeijneman, Jorin$$b6
000281814 7001_ $$aMiramontes, Ricardo$$b7
000281814 7001_ $$aPömpner, Nadine$$b8
000281814 7001_ $$aBlomberg, Niek$$b9
000281814 7001_ $$00000-0002-6363-0857$$aOlivier-Jimenez, Damien$$b10
000281814 7001_ $$00000-0003-2187-6709$$aJohansen, Lill Eva$$b11
000281814 7001_ $$aCammack, Alexander J$$b12
000281814 7001_ $$aGiblin, Ashling$$b13
000281814 7001_ $$00000-0002-5146-3326$$aToomey, Christina E$$b14
000281814 7001_ $$00000-0003-0491-1269$$aRose, Indigo V L$$b15
000281814 7001_ $$aYuan, Hebao$$b16
000281814 7001_ $$aWard, Michael E$$b17
000281814 7001_ $$aIsaacs, Adrian M$$b18
000281814 7001_ $$00000-0002-3819-7019$$aKampmann, Martin$$b19
000281814 7001_ $$0P:(DE-2719)9001451$$aKronenberg-Versteeg, Deborah$$b20$$udzne
000281814 7001_ $$aLashley, Tammaryn$$b21
000281814 7001_ $$aThompson, Leslie M$$b22
000281814 7001_ $$00000-0002-3046-0871$$aOri, Alessandro$$b23
000281814 7001_ $$00000-0003-3265-3332$$aMohammed, Yassene$$b24
000281814 7001_ $$00000-0003-1684-1894$$aGiera, Martin$$b25
000281814 7001_ $$00000-0002-7023-0106$$avan der Kant, Rik$$b26
000281814 773__ $$0PERI:(DE-600)2933873-6$$a10.1038/s42255-025-01365-z$$gVol. 7, no. 10, p. 2142 - 2164$$n10$$p2142 - 2164$$tNature metabolism$$v7$$x2522-5812$$y2025
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