Home > Publications Database > The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases. > print

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100 1 _ |a Feringa, Femke M
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245 _ _ |a The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases.
260 _ _ |a [London]
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|b Springer Nature
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520 _ _ |a Lipid alterations in the brain have been implicated in many neurodegenerative diseases. To facilitate comparative lipidomic research across brain diseases, we establish a data common named the Neurolipid Atlas that we prepopulated with isogenic induced pluripotent stem cell (iPS cell)-derived lipidomics data for different brain diseases. Additionally, the resource contains lipidomics data of human and mouse brain tissue. Leveraging multiple datasets, we demonstrate that iPS cell-derived neurons, microglia and astrocytes exhibit distinct lipid profiles that recapitulate in vivo lipotypes. Notably, the Alzheimer disease (AD) risk gene ApoE4 drives cholesterol ester (CE) accumulation specifically in human astrocytes and we also observe CE accumulation in whole-brain lipidomics from persons with AD. Multiomics interrogation of iPS cell-derived astrocytes revealed that altered cholesterol metabolism has a major role in astrocyte immune pathways such as the immunoproteasome and major histocompatibility complex class I antigen presentation. Our data commons, available online ( https://neurolipidatlas.com/ ), allows for data deposition by the community and provides a user-friendly tool and knowledge base for a better understanding of lipid dyshomeostasis in neurodegenerative diseases.
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650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Lipidomics: methods
|2 MeSH
650 _ 2 |a Neurodegenerative Diseases: metabolism
|2 MeSH
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Mice
|2 MeSH
650 _ 2 |a Astrocytes: metabolism
|2 MeSH
650 _ 2 |a Lipid Metabolism
|2 MeSH
650 _ 2 |a Induced Pluripotent Stem Cells: metabolism
|2 MeSH
650 _ 2 |a Brain: metabolism
|2 MeSH
650 _ 2 |a Neurons: metabolism
|2 MeSH
650 _ 2 |a Alzheimer Disease: metabolism
|2 MeSH
650 _ 2 |a Microglia: metabolism
|2 MeSH
700 1 _ |a Koppes-den Hertog, Sascha J
|0 0000-0002-7372-8946
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700 1 _ |a Wang, Lian Y
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700 1 _ |a Derks, Rico J E
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700 1 _ |a Kruijff, Iris
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700 1 _ |a Erlebach, Lena
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700 1 _ |a Heijneman, Jorin
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700 1 _ |a Miramontes, Ricardo
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700 1 _ |a Pömpner, Nadine
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700 1 _ |a Blomberg, Niek
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700 1 _ |a Olivier-Jimenez, Damien
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700 1 _ |a Johansen, Lill Eva
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700 1 _ |a Cammack, Alexander J
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700 1 _ |a Giblin, Ashling
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700 1 _ |a Toomey, Christina E
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700 1 _ |a Rose, Indigo V L
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700 1 _ |a Yuan, Hebao
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700 1 _ |a Ward, Michael E
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700 1 _ |a Isaacs, Adrian M
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700 1 _ |a Kampmann, Martin
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700 1 _ |a Kronenberg-Versteeg, Deborah
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700 1 _ |a Lashley, Tammaryn
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700 1 _ |a Thompson, Leslie M
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700 1 _ |a Ori, Alessandro
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700 1 _ |a Mohammed, Yassene
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700 1 _ |a Giera, Martin
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700 1 _ |a van der Kant, Rik
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773 _ _ |a 10.1038/s42255-025-01365-z
|g Vol. 7, no. 10, p. 2142 - 2164
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856 4 _ |u https://pub.dzne.de/record/281814/files/DZNE-2025-01196%20SUP.zip
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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