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@ARTICLE{Palleis:281815,
author = {Palleis, Carla and Quattrone, Andrea and Dehsarvi, Amir and
Roemer-Cassiano, Sebastian N and Bernhardt, Alexander
Maximilian and Huppertz, Hans-Jürgen and Malpetti, Maura
and Boxer, Adam L and Gnoerich, Johannes and Frontzkowski,
Lukas and Levin, Johannes and Brendel, Matthias and
Höglinger, Günter U and Franzmeier, Nicolai},
collaboration = {AL-108-231 Investigators, the PASSPORT Study Group},
othercontributors = {Aiba, Ikuko and Antonini, Angelo and Apetauerova, Diana and
Azulay, Jean-Philippe and Martinez, Ernest Balaguer and
Bang, Jee and Barone, Paolo and Barrett, Matthew and Bega,
Danny and Berg, Daniela and Corrales, Koldo Berganzo and
Bordelon, Yvette and Boxer, Adam L and Brandt, Daniel Moritz
and Brueggemann, Norbert and Castelnovo, Giovanni and
Ceravolo, Roberto and Chuang, Rosalind and Chung, Sun Ju and
Church, Alistair and Corvol, Jean-Christophe and Cudia,
Paola and Dale, Marian and Defebvre, Luc and Drapier, Sophie
and Driver-Dunckley, Erika D and Ebersbach, Georg and
Eggert, Karla M and Ellenbogen, Aaron and Eusebio, Alexandre
and Evans, Andrew H and Fedorova, Natalia and Finger,
Elizabeth and Foubert-Samier, Alexandra and Ghosh, Boyd and
Golbe, Lawrence and Perez, Francisco Grandas and Grossman,
Murray and Hall, Deborah and Hamada, Kyoko and Hasegawa,
Kazuko and Hoeglinger, Guenter and Honig, Lawrence and
Houghton, David and Huang, Xuemei and Isaacson, Stuart and
Bojarski, Jaime Kulisevsky and Lang, Anthony E and Leigh,
Peter Nigel and Research, Biomedical and Litvan, Irene and
Lozano, Juan Jose Lopez and Moreno, Jose Luis Lopez-Sendon
and Ludolph, Albert and Piudo, Ma Rosario Luquin and Torres,
Irene Martinez and McFarland, Nikolaus and Meissner,
Wassilios and Mestre, Tiago and Rivera, Pablo Mir and Molho,
Eric and Mollenhauer, Britt and Morris, Huw R and Murata,
Miho and Obi, Tomokazu and Magne, Fabienne Ory and
O'Suilleabhain, Padraig and Pahwa, Rajesh and Pantelyat,
Alexander and Pavese, Nicola and Pokhabov, Dmitry and
Prudlo, Johannes and Rodriguez-Porcel, Federico and Rowe,
James and Savitt, Joseph and Schnitzler, Alfons and Schulz,
Joerg B and Seppi, Klaus and Shah, Binit and Shill, Holly
and Shprecher, David and Stamelou, Maria and Steiger,
Malcolm and Takahashi, Yuji and Takigawa, Hiroshi and
Tartaglia, Carmela and Toenges, Lars and Studienambulanz,
Kardiologische and Truong, Daniel and Tse, Winona and Tuite,
Paul and Volc, Dieter and Wills, Anne-Marie A and Woitalla,
Dirk and Xie, Tao and Yuasa, Tatsuhiko and Zauber, Sarah
Elizabeth and Zesiewicz, Theresa and Williams, David and
Lafontaine, Anne Louise and Marras, Connie and Jog, Mandar
and Panisset, Michael and Lang, Anthony and Parker, Lesley
and Stewart, Alistair J and Corvol, Jean-Christophe and
Azulay, Jean-Philippe and Couratier, Philippe and
Mollenhauer, Brit and Lorenzl, Stefan and Ludolph, Albert
and Benecke, Reiner and Höglinger, Günter and Lipp, Axel
and Reichmann, Heinz and Woitalla, Dirk and Chan, Dennis and
Zermansky, Adam and Burn, David and Lees, Andrew and Boxer,
Adam and Miller, Bruce L and Lobach, Iryna V and Roberson,
Erik and Honig, Lawrence and Zamrini, Edward and Pahwa,
Rajesh and Bor-Delon, Yvette and Driver-Dunkley, Erika and
Lessig, Stephanie and Lew, Mark and Womack, Kyle and Boeve,
Brad and Ferrara, Joseph and Hillis, Argyle and Kaufer,
Daniel and Kumar, Rajeev and Xie, Tao and Gunzler, Steven
and Zesiewicz, Theresa and Dayalu, Praveen and Golbe,
Lawrence and Grossman, Murray and Jancovic, Joseph and
McGinnis, Scott and Santiago, Anthony and Tuite, Paul and
Isaacson, Stuart and Leegwater-Kim, Julie and Litvan, Irene
and Grossman, Murray and Knopman, David S and Miller, Bruce
L and Schneider, Lon S and Doody, Rachelle S and Golbe,
Lawrence I and Roberson, Erik D and Koestler, Mary and Jack,
Clifford R and Van Deerlin, Viviana and Randolph,
Christopher and Lobach, Iryna V and Gozes, Illana and
Whitaker, Steve and Hirman, Joe and Gold, Michael and
Morimoto, Bruce H},
title = {{B}rain {N}etworks {R}oute {N}eurodegeneration {P}atterns
in {P}atients with {P}rogressive {S}upranuclear {P}alsy.},
journal = {Movement disorders},
volume = {40},
number = {10},
issn = {0885-3185},
address = {New York, NY},
publisher = {Wiley},
reportid = {DZNE-2025-01197},
pages = {2102 - 2115},
year = {2025},
abstract = {Progressive supranuclear palsy (PSP) is a neurodegenerative
disease driven by 4-repeat τ pathology, which is thought to
propagate across interconnected neurons.We hypothesized that
interconnected brain regions exhibit correlated atrophy, and
that atrophy propagates network-like from fast-declining
epicenters to connected regions in PSP.We combined
resting-state functional magnetic resonance imaging (fMRI)
connectomics with two independent 12-month longitudinal
structural magnetic resonance imaging (MRI) datasets of
PSP-Richardson syndrome (PSP-RS) patients
(ndiscovery/nvalidation = 114/90). MRI-based gray matter
volumes were assessed for 246 regions of the Brainnetome
atlas and converted to w-scores indicating local atrophy
(ie, volumes adjusted for age, sex, and intracranial volume
based on regression models determined in a sample of 377
healthy amyloid- and τ-negative controls from the
Alzheimer's Disease Neuroimaging Initiative [ADNI]). Annual
volume changes were determined for each Brainnetome region
of interest using longitudinal structural MRI. Resting-state
fMRI from 69 ADNI healthy controls was used to determine a
connectivity template.We observed pronounced atrophy and
volume decline in the frontal lobe and subcortical regions
bilaterally. Correlated atrophy and volume changes were
found among interconnected brain regions, with regions with
severe atrophy or rapid decline being strongly connected to
similarly affected areas, whereas minimally affected regions
were connected to less affected areas. Connectivity patterns
of atrophy epicenters predicted patient level atrophy and
volume decline.Our findings show that key subcortical and
frontal brain regions undergo atrophy in PSP-RS and that
gray matter atrophy expands across interconnected brain
regions, supporting the view that neurodegeneration patterns
may follow the trans-neuronal τ propagation pattern in
PSP-RS. © 2025 The Author(s). Movement Disorders published
by Wiley Periodicals LLC on behalf of International
Parkinson and Movement Disorder Society.},
keywords = {Humans / Supranuclear Palsy, Progressive: diagnostic
imaging / Supranuclear Palsy, Progressive: pathology /
Supranuclear Palsy, Progressive: physiopathology / Male /
Female / Magnetic Resonance Imaging / Aged / Brain:
pathology / Brain: diagnostic imaging / Brain:
physiopathology / Middle Aged / Atrophy: pathology / Gray
Matter: pathology / Gray Matter: diagnostic imaging /
Connectome / Nerve Net: diagnostic imaging / Nerve Net:
pathology / Nerve Net: physiopathology / Longitudinal
Studies / PSP (Other) / functional connectivity (Other) /
gray matter atrophy (Other) / imaging (Other) / tauopathies
(Other)},
cin = {Clinical Research (Munich) / AG Levin / AG Haass},
ddc = {610},
cid = {I:(DE-2719)1111015 / I:(DE-2719)1111016 /
I:(DE-2719)1110007},
pnm = {353 - Clinical and Health Care Research (POF4-353) / 352 -
Disease Mechanisms (POF4-352)},
pid = {G:(DE-HGF)POF4-353 / G:(DE-HGF)POF4-352},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:40485628},
doi = {10.1002/mds.30257},
url = {https://pub.dzne.de/record/281815},
}
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