%0 Journal Article
%A Wisch, Julie K
%A McKay, Nicole S
%A Zammit, Matthew
%A Christian, Bradley T
%A Schultz, Stephanie A
%A Millar, Peter R
%A Ryan, Natalie S
%A Cash, David M
%A Belder, Christopher R S
%A Chrem, Patricio
%A Cruchaga, Carlos
%A Ibanez, Laura
%A Jucker, Mathias
%A Yakushev, Igor
%A Day, Gregory S
%A Murphy, Mei
%A Llibre-Guerra, Jorge
%A Aguillon, David
%A Roh, Jee Hoon
%A Xiong, Chengjie
%A Wang, Guoqiao
%A Li, Yan
%A Schindler, Suzanne E
%A Jack, Cliff
%A McDade, Eric
%A Bateman, Randall J
%A Benzinger, Tammie L S
%A Ances, Beau M
%A Betthauser, Tobey
%A Gordon, Brian
%T Comparison of amyloid chronicity and EYO in autosomal dominant Alzheimer's disease.
%J Alzheimer's and dementia
%V 21
%N 10
%@ 1552-5260
%C Hoboken, NJ
%I Wiley
%M DZNE-2025-01198
%P e70812
%D 2025
%X Preclinical Alzheimer's disease (AD) can be described relative to biomarker positivity onset time.We estimated time from amyloid positivity (A+) using sampled iterative local approximation (SILA) in a longitudinal autosomal dominant AD (ADAD) sample (N = 379) with amyloid positron emission tomography. We compared (1) predicted age at A+ to imputed age, (2) estimated age at A+ to estimated age at symptom onset, and (3) variance in cognitive performance explained.Mean error between imputed and SILA-estimated age at A+ (N = 26) was 1.15 years. Age at A+ explained 39
%K Humans
%K Alzheimer Disease: genetics
%K Alzheimer Disease: diagnostic imaging
%K Alzheimer Disease: pathology
%K Alzheimer Disease: metabolism
%K Male
%K Female
%K Positron-Emission Tomography
%K Middle Aged
%K Age of Onset
%K Longitudinal Studies
%K Aged
%K Biomarkers
%K Disease Progression
%K Amyloid: metabolism
%K Amyloid beta-Peptides: metabolism
%K Alzheimer's disease (Other)
%K biomarkers (Other)
%K genetic causes of Alzheimer's disease (Other)
%K numeric methods (Other)
%K Biomarkers (NLM Chemicals)
%K Amyloid (NLM Chemicals)
%K Amyloid beta-Peptides (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:41137622
%R 10.1002/alz.70812
%U https://pub.dzne.de/record/281816