TY  - JOUR
AU  - Wisch, Julie K
AU  - McKay, Nicole S
AU  - Zammit, Matthew
AU  - Christian, Bradley T
AU  - Schultz, Stephanie A
AU  - Millar, Peter R
AU  - Ryan, Natalie S
AU  - Cash, David M
AU  - Belder, Christopher R S
AU  - Chrem, Patricio
AU  - Cruchaga, Carlos
AU  - Ibanez, Laura
AU  - Jucker, Mathias
AU  - Yakushev, Igor
AU  - Day, Gregory S
AU  - Murphy, Mei
AU  - Llibre-Guerra, Jorge
AU  - Aguillon, David
AU  - Roh, Jee Hoon
AU  - Xiong, Chengjie
AU  - Wang, Guoqiao
AU  - Li, Yan
AU  - Schindler, Suzanne E
AU  - Jack, Cliff
AU  - McDade, Eric
AU  - Bateman, Randall J
AU  - Benzinger, Tammie L S
AU  - Ances, Beau M
AU  - Betthauser, Tobey
AU  - Gordon, Brian
TI  - Comparison of amyloid chronicity and EYO in autosomal dominant Alzheimer's disease.
JO  - Alzheimer's and dementia
VL  - 21
IS  - 10
SN  - 1552-5260
CY  - Hoboken, NJ
PB  - Wiley
M1  - DZNE-2025-01198
SP  - e70812
PY  - 2025
AB  - Preclinical Alzheimer's disease (AD) can be described relative to biomarker positivity onset time.We estimated time from amyloid positivity (A+) using sampled iterative local approximation (SILA) in a longitudinal autosomal dominant AD (ADAD) sample (N = 379) with amyloid positron emission tomography. We compared (1) predicted age at A+ to imputed age, (2) estimated age at A+ to estimated age at symptom onset, and (3) variance in cognitive performance explained.Mean error between imputed and SILA-estimated age at A+ (N = 26) was 1.15 years. Age at A+ explained 39
KW  - Humans
KW  - Alzheimer Disease: genetics
KW  - Alzheimer Disease: diagnostic imaging
KW  - Alzheimer Disease: pathology
KW  - Alzheimer Disease: metabolism
KW  - Male
KW  - Female
KW  - Positron-Emission Tomography
KW  - Middle Aged
KW  - Age of Onset
KW  - Longitudinal Studies
KW  - Aged
KW  - Biomarkers
KW  - Disease Progression
KW  - Amyloid: metabolism
KW  - Amyloid beta-Peptides: metabolism
KW  - Alzheimer's disease (Other)
KW  - biomarkers (Other)
KW  - genetic causes of Alzheimer's disease (Other)
KW  - numeric methods (Other)
KW  - Biomarkers (NLM Chemicals)
KW  - Amyloid (NLM Chemicals)
KW  - Amyloid beta-Peptides (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:41137622
DO  - DOI:10.1002/alz.70812
UR  - https://pub.dzne.de/record/281816
ER  -