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000281820 041__ $$aEnglish
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000281820 1001_ $$00000-0003-4847-4144$$aReshetniak, Sofiia$$b0
000281820 245__ $$aThe synaptic vesicle cluster as a controller of pre- and postsynaptic structure and function.
000281820 260__ $$aHoboken, NJ$$bWiley-Blackwell$$c2025
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000281820 520__ $$aThe synaptic vesicle cluster (SVC) is an essential component of chemical synapses, which provides neurotransmitter-loaded vesicles during synaptic activity, at the same time as also controlling the local concentrations of numerous exo- and endocytosis cofactors. In addition, the SVC hosts molecules that participate in other aspects of synaptic function, from cytoskeletal components to adhesion proteins, and affects the location and function of organelles such as mitochondria and the endoplasmic reticulum. We argue here that these features extend the functional involvement of the SVC in synapse formation, signalling and plasticity, as well as synapse stabilization and metabolism. We also propose that changes in the size of the SVC coalesce with changes in the postsynaptic compartment, supporting the interplay between pre- and postsynaptic dynamics. Thereby, the SVC could be seen as an 'all-in-one' regulator of synaptic structure and function, which should be investigated in more detail, to reveal molecular mechanisms that control synaptic function and heterogeneity.
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000281820 650_7 $$2Other$$asynapse
000281820 650_7 $$2Other$$asynapse formation
000281820 650_7 $$2Other$$asynaptic plasticity
000281820 650_7 $$2Other$$asynaptic vesicle cluster
000281820 650_7 $$2Other$$avesicle
000281820 650_2 $$2MeSH$$aSynaptic Vesicles: physiology
000281820 650_2 $$2MeSH$$aAnimals
000281820 650_2 $$2MeSH$$aHumans
000281820 650_2 $$2MeSH$$aSynapses: physiology
000281820 650_2 $$2MeSH$$aSynaptic Transmission: physiology
000281820 650_2 $$2MeSH$$aPresynaptic Terminals: physiology
000281820 7001_ $$00009-0004-7781-7040$$aBogaciu, Cristian A$$b1
000281820 7001_ $$0P:(DE-2719)2810547$$aBonn, Stefan$$b2
000281820 7001_ $$aBrose, Nils$$b3
000281820 7001_ $$aCooper, Benjamin H$$b4
000281820 7001_ $$aD'Este, Elisa$$b5
000281820 7001_ $$aFauth, Michael$$b6
000281820 7001_ $$00000-0002-8366-7622$$aFernández-Busnadiego, Rubén$$b7
000281820 7001_ $$aFiosins, Maksims$$b8
000281820 7001_ $$0P:(DE-2719)2000047$$aFischer, André$$b9
000281820 7001_ $$aGeorgiev, Svilen V$$b10
000281820 7001_ $$aJakobs, Stefan$$b11
000281820 7001_ $$00000-0003-0584-2146$$aKlumpp, Stefan$$b12
000281820 7001_ $$aKöster, Sarah$$b13
000281820 7001_ $$00000-0003-1135-0797$$aLange, Felix$$b14
000281820 7001_ $$00000-0002-0755-5899$$aLipstein, Noa$$b15
000281820 7001_ $$00000-0001-7788-4914$$aMacarrón-Palacios, Victor$$b16
000281820 7001_ $$0P:(DE-2719)9000670$$aMilovanovic, Dragomir$$b17
000281820 7001_ $$00000-0001-7145-0533$$aMoser, Tobias$$b18
000281820 7001_ $$00000-0002-7472-973X$$aMüller, Marcus$$b19
000281820 7001_ $$00000-0002-4968-9713$$aOpazo, Felipe$$b20
000281820 7001_ $$0P:(DE-2719)2814138$$aOuteiro, Tiago$$b21$$udzne
000281820 7001_ $$aPape, Constantin$$b22
000281820 7001_ $$aPriesemann, Viola$$b23
000281820 7001_ $$00000-0001-5661-5272$$aRehling, Peter$$b24
000281820 7001_ $$aSalditt, Tim$$b25
000281820 7001_ $$aSchlüter, Oliver$$b26
000281820 7001_ $$00000-0001-8130-883X$$aSimeth, Nadja$$b27
000281820 7001_ $$aSteinem, Claudia$$b28
000281820 7001_ $$aTchumatchenko, Tatjana$$b29
000281820 7001_ $$aTetzlaff, Christian$$b30
000281820 7001_ $$00000-0002-5669-9610$$aTirard, Marilyn$$b31
000281820 7001_ $$aUrlaub, Henning$$b32
000281820 7001_ $$aWichmann, Carolin$$b33
000281820 7001_ $$aWolf, Fred$$b34
000281820 7001_ $$00000-0002-1667-7839$$aRizzoli, Silvio O$$b35
000281820 770__ $$aThe giant impact of synapses on brain function and disease
000281820 773__ $$0PERI:(DE-600)1475290-6$$a10.1113/JP286400$$gVol. 603, no. 20, p. 5935 - 5964$$n20$$p5935 - 5964$$tThe journal of physiology$$v603$$x0022-3751$$y2025
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