TY  - JOUR
AU  - Reshetniak, Sofiia
AU  - Bogaciu, Cristian A
AU  - Bonn, Stefan
AU  - Brose, Nils
AU  - Cooper, Benjamin H
AU  - D'Este, Elisa
AU  - Fauth, Michael
AU  - Fernández-Busnadiego, Rubén
AU  - Fiosins, Maksims
AU  - Fischer, André
AU  - Georgiev, Svilen V
AU  - Jakobs, Stefan
AU  - Klumpp, Stefan
AU  - Köster, Sarah
AU  - Lange, Felix
AU  - Lipstein, Noa
AU  - Macarrón-Palacios, Victor
AU  - Milovanovic, Dragomir
AU  - Moser, Tobias
AU  - Müller, Marcus
AU  - Opazo, Felipe
AU  - Outeiro, Tiago
AU  - Pape, Constantin
AU  - Priesemann, Viola
AU  - Rehling, Peter
AU  - Salditt, Tim
AU  - Schlüter, Oliver
AU  - Simeth, Nadja
AU  - Steinem, Claudia
AU  - Tchumatchenko, Tatjana
AU  - Tetzlaff, Christian
AU  - Tirard, Marilyn
AU  - Urlaub, Henning
AU  - Wichmann, Carolin
AU  - Wolf, Fred
AU  - Rizzoli, Silvio O
TI  - The synaptic vesicle cluster as a controller of pre- and postsynaptic structure and function.
JO  - The journal of physiology
VL  - 603
IS  - 20
SN  - 0022-3751
CY  - Hoboken, NJ
PB  - Wiley-Blackwell
M1  - DZNE-2025-01201
SP  - 5935 - 5964
PY  - 2025
AB  - The synaptic vesicle cluster (SVC) is an essential component of chemical synapses, which provides neurotransmitter-loaded vesicles during synaptic activity, at the same time as also controlling the local concentrations of numerous exo- and endocytosis cofactors. In addition, the SVC hosts molecules that participate in other aspects of synaptic function, from cytoskeletal components to adhesion proteins, and affects the location and function of organelles such as mitochondria and the endoplasmic reticulum. We argue here that these features extend the functional involvement of the SVC in synapse formation, signalling and plasticity, as well as synapse stabilization and metabolism. We also propose that changes in the size of the SVC coalesce with changes in the postsynaptic compartment, supporting the interplay between pre- and postsynaptic dynamics. Thereby, the SVC could be seen as an 'all-in-one' regulator of synaptic structure and function, which should be investigated in more detail, to reveal molecular mechanisms that control synaptic function and heterogeneity.
KW  - Synaptic Vesicles: physiology
KW  - Animals
KW  - Humans
KW  - Synapses: physiology
KW  - Synaptic Transmission: physiology
KW  - Presynaptic Terminals: physiology
KW  - synapse (Other)
KW  - synapse formation (Other)
KW  - synaptic plasticity (Other)
KW  - synaptic vesicle cluster (Other)
KW  - vesicle (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:39367860
DO  - DOI:10.1113/JP286400
UR  - https://pub.dzne.de/record/281820
ER  -