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000281827 0247_ $$2doi$$a10.1002/alz.70727
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000281827 0247_ $$2ISSN$$a1552-5279
000281827 037__ $$aDZNE-2025-01208
000281827 041__ $$aEnglish
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000281827 1001_ $$0P:(DE-2719)9001134$$aRädke, Anika$$b0$$eFirst author$$udzne
000281827 245__ $$aEfficacy and cost-effectiveness of extended nursing roles in dementia care: Results of the cluster-randomized trial InDePendent.
000281827 260__ $$aHoboken, NJ$$bWiley$$c2025
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000281827 520__ $$aExtended nursing roles in dementia can improve treatment, care, and patient and caregiver outcomes. We tested the efficacy and cost-effectiveness in people living with dementia (PlwD) and caregivers.We analyzed data from 417 PlwD within the multicenter, cluster-randomized InDePendent trial six months after baseline. Specifically, qualified nurses carried out advanced dementia care management individually tailored to each patient's and caregiver's needs. Outcomes included unmet needs (CANE), quality of life (QoL-AD, EQ-5D), caregiver burden (Zarit), and cost-effectiveness (FIMA, RUD).PlwD receiving the intervention had 74% lower unmet needs (0.26, CI95%: 0.17 to 0.40, p < 0.001) and higher quality of life (0.04, CI95%: 0.01 to 0.07, p = 0.017) than controls. There was a gain in quality-adjusted life years (0.01, CI95%: -0.001 to 0.018) at slightly higher costs (1,425 EUR, CI95%: 638 to 2,211). There was no effect on caregiver burden after six months.The results provide evidence for the efficacy and cost-effectiveness of extended nursing roles in dementia care, demonstrating that extended nursing roles reduce unmet needs and improve quality of life.This trial was prospectively registered on ClinicalTrials.gov under the identifier NCT04741932 on February 2, 2021.The InDePendent intervention significantly reduced the number of unmet needs in PlwD and their caregiver according to CANE. Extended nursing roles can improve PlwD's health-related Quality of Life. Advanced dementia care management were likely to be cost-effective after six months.
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000281827 650_7 $$2Other$$aadvanced nursing
000281827 650_7 $$2Other$$acost‐effectiveness
000281827 650_7 $$2Other$$adementia
000281827 650_7 $$2Other$$aprimary care
000281827 650_7 $$2Other$$arandomized controlled trial
000281827 650_7 $$2Other$$aunmet needs
000281827 650_2 $$2MeSH$$aHumans
000281827 650_2 $$2MeSH$$aDementia: nursing
000281827 650_2 $$2MeSH$$aDementia: economics
000281827 650_2 $$2MeSH$$aCost-Benefit Analysis
000281827 650_2 $$2MeSH$$aCaregivers: psychology
000281827 650_2 $$2MeSH$$aFemale
000281827 650_2 $$2MeSH$$aMale
000281827 650_2 $$2MeSH$$aQuality of Life
000281827 650_2 $$2MeSH$$aAged
000281827 650_2 $$2MeSH$$aNurse's Role
000281827 650_2 $$2MeSH$$aAged, 80 and over
000281827 650_2 $$2MeSH$$aQuality-Adjusted Life Years
000281827 7001_ $$0P:(DE-2719)2810763$$aMichalowsky, Bernhard$$b1$$udzne
000281827 7001_ $$0P:(DE-HGF)0$$aKleinke, Fabian$$b2
000281827 7001_ $$0P:(DE-2719)9001238$$aPlaten, Moritz$$b3$$udzne
000281827 7001_ $$0P:(DE-2719)9001251$$aScharf, Annelie$$b4$$udzne
000281827 7001_ $$0P:(DE-2719)9002113$$aPfaff, Michelle$$b5$$udzne
000281827 7001_ $$0P:(DE-2719)9002138$$aBuchholz, Maresa$$b6$$udzne
000281827 7001_ $$0P:(DE-2719)9001235$$aMühlichen, Franka$$b7$$udzne
000281827 7001_ $$aPenndorf, Peter$$b8
000281827 7001_ $$aSchade, Stefanie$$b9
000281827 7001_ $$aDombrowski, Janina$$b10
000281827 7001_ $$aLerch, Pia Elisa Madaida$$b11
000281827 7001_ $$aReber, Katrin Christiane$$b12
000281827 7001_ $$aAustenat-Wied, Manon$$b13
000281827 7001_ $$aMartens, Cornelia$$b14
000281827 7001_ $$avan den Berg, Neeltje$$b15
000281827 7001_ $$0P:(DE-2719)2000040$$aHoffmann, Wolfgang$$b16$$eLast author$$udzne
000281827 773__ $$0PERI:(DE-600)2201940-6$$a10.1002/alz.70727$$gVol. 21, no. 10, p. e70727$$n10$$pe70727$$tAlzheimer's and dementia$$v21$$x1552-5260$$y2025
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