% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Rdke:281827,
      author       = {Rädke, Anika and Michalowsky, Bernhard and Kleinke, Fabian
                      and Platen, Moritz and Scharf, Annelie and Pfaff, Michelle
                      and Buchholz, Maresa and Mühlichen, Franka and Penndorf,
                      Peter and Schade, Stefanie and Dombrowski, Janina and Lerch,
                      Pia Elisa Madaida and Reber, Katrin Christiane and
                      Austenat-Wied, Manon and Martens, Cornelia and van den Berg,
                      Neeltje and Hoffmann, Wolfgang},
      title        = {{E}fficacy and cost-effectiveness of extended nursing roles
                      in dementia care: {R}esults of the cluster-randomized trial
                      {I}n{D}e{P}endent.},
      journal      = {Alzheimer's and dementia},
      volume       = {21},
      number       = {10},
      issn         = {1552-5260},
      address      = {Hoboken, NJ},
      publisher    = {Wiley},
      reportid     = {DZNE-2025-01208},
      pages        = {e70727},
      year         = {2025},
      abstract     = {Extended nursing roles in dementia can improve treatment,
                      care, and patient and caregiver outcomes. We tested the
                      efficacy and cost-effectiveness in people living with
                      dementia (PlwD) and caregivers.We analyzed data from 417
                      PlwD within the multicenter, cluster-randomized InDePendent
                      trial six months after baseline. Specifically, qualified
                      nurses carried out advanced dementia care management
                      individually tailored to each patient's and caregiver's
                      needs. Outcomes included unmet needs (CANE), quality of life
                      (QoL-AD, EQ-5D), caregiver burden (Zarit), and
                      cost-effectiveness (FIMA, RUD).PlwD receiving the
                      intervention had $74\%$ lower unmet needs (0.26, $CI95\%:$
                      0.17 to 0.40, p < 0.001) and higher quality of life (0.04,
                      $CI95\%:$ 0.01 to 0.07, p = 0.017) than controls. There was
                      a gain in quality-adjusted life years (0.01, $CI95\%:$
                      -0.001 to 0.018) at slightly higher costs (1,425 EUR,
                      $CI95\%:$ 638 to 2,211). There was no effect on caregiver
                      burden after six months.The results provide evidence for the
                      efficacy and cost-effectiveness of extended nursing roles in
                      dementia care, demonstrating that extended nursing roles
                      reduce unmet needs and improve quality of life.This trial
                      was prospectively registered on ClinicalTrials.gov under the
                      identifier NCT04741932 on February 2, 2021.The InDePendent
                      intervention significantly reduced the number of unmet needs
                      in PlwD and their caregiver according to CANE. Extended
                      nursing roles can improve PlwD's health-related Quality of
                      Life. Advanced dementia care management were likely to be
                      cost-effective after six months.},
      keywords     = {Humans / Dementia: nursing / Dementia: economics /
                      Cost-Benefit Analysis / Caregivers: psychology / Female /
                      Male / Quality of Life / Aged / Nurse's Role / Aged, 80 and
                      over / Quality-Adjusted Life Years / advanced nursing
                      (Other) / cost‐effectiveness (Other) / dementia (Other) /
                      primary care (Other) / randomized controlled trial (Other) /
                      unmet needs (Other)},
      cin          = {AG Hoffmann / AG Michalowsky},
      ddc          = {610},
      cid          = {I:(DE-2719)1510600 / I:(DE-2719)5000067},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41143334},
      pmc          = {pmc:PMC12556587},
      doi          = {10.1002/alz.70727},
      url          = {https://pub.dzne.de/record/281827},
}