TY  - JOUR
AU  - Klinger-König, Johanna
AU  - Streit, Fabian
AU  - Völker, Maja P
AU  - Frank, Josef
AU  - Sekula, Peggy
AU  - Jaskulski, Stefanie
AU  - Leitzmann, Michael
AU  - Meinke-Franze, Claudia
AU  - Schmidt, Carsten O
AU  - Keil, Thomas
AU  - Willich, Stefan N
AU  - Pischon, Tobias
AU  - Velásquez, Ilais M
AU  - Frost, Jonas
AU  - Schmidt, Börge
AU  - Heise, Jana-Kristin
AU  - Klett-Tammen, Carolina J
AU  - Koch-Gallenkamp, Lena
AU  - Obi, Nadia
AU  - Harth, Volker
AU  - Mons, Ute
AU  - Berger, Klaus
AU  - Greiser, Karin H
AU  - Mikolajczyk, Rafael
AU  - Schulze, Matthias B
AU  - Grabe, Hans J
TI  - Childhood maltreatment and adult diseases in the general population: the mediating role of smoking and overweight in a time-sequence design.
JO  - BMC public health
VL  - 25
IS  - 1
SN  - 1471-2458
CY  - London
PB  - BioMed Central
M1  - DZNE-2025-01211
SP  - 3613
PY  - 2025
AB  - Childhood maltreatment is associated with an unhealthier lifestyle in adulthood and an increased risk of mental and somatic health problems, although the underlying pathways remain unclear. This study examined whether smoking and overweight mediate the association between childhood abuse/neglect and frequent adult diseases, including cancer, myocardial infarction, stroke, type 2 diabetes, chronic obstructive pulmonary disease, depression, and anxiety.Childhood maltreatment was assessed in 152,887 German National Cohort (NAKO) participants using the Childhood Trauma Screener. Information on smoking initiation age, weight history, and respective age at diagnosis was incorporated to ensure that smoking and overweight preceded the diagnosis. Mediation analyses were adjusted for age, sex, study center, and education.For childhood abuse, larger proportions of associations with adult somatic diseases were mediated through preexisting smoking and overweight compared to adult mental disorders. Smoking most strongly mediated myocardial infarction (36.88
KW  - Age of onset (Other)
KW  - Childhood abuse (Other)
KW  - Childhood neglect (Other)
KW  - Chronic non-communicable diseases (Other)
KW  - Mental health (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:41146110
C2  - pmc:PMC12560492
DO  - DOI:10.1186/s12889-025-24854-y
UR  - https://pub.dzne.de/record/281830
ER  -