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@ARTICLE{Reetz:281831,
      author       = {Reetz, Kathrin and Costa, Ana Sofia and Michels, Jennifer
                      and Albrecht, Milena and Moschko, Pia and Pahl, Jennifer and
                      Häger, Alexa and Schuckelt, Rainer and Röhrig, Rainer and
                      Wienströer, Jan and Flöel, Agnes and Düzel, Emrah and
                      Onur, Oezguer A and Grimmer, Timo and Levin, Johannes and
                      Frölich, Lutz and Jessen, Frank and Schulz, Jörg B},
      collaboration = {Registry, German Dementia},
      othercontributors = {Polivka, Dörte and Duning, Thomas and Gutschalk, Alexander
                          and Oberstein, Timo and Schnieder, Marlena and
                          Trender-Gerhard, Iris and Laske, Christoph and Dahling,
                          Volker and Peters, Oliver and Saur, Dorothee and Spruth,
                          Eike Jakob and Cheng, Bastian and Fußer, Fabian and
                          Bartsch, Thorsten and Glanz, Wenzel and Hausner, Lucrezia
                          and Riemenschneider, Matthias and Höltje, Esther and
                          Hellmann-Regen, Julian David Nicolai},
      title        = {{T}he {G}erman {D}ementia {R}egistry ({DEMREG}): study
                      protocol of a biomarker-based national registry for
                      cognitive impairment and dementia.},
      journal      = {Neurological research and practice},
      volume       = {7},
      number       = {1},
      issn         = {2524-3489},
      address      = {[London]},
      publisher    = {BioMed Central},
      reportid     = {DZNE-2025-01212},
      pages        = {80},
      year         = {2025},
      abstract     = {The German Dementia Registry (DEMREG) is a large-scale
                      national prospective biomarker-based study for cognitive
                      impairment and dementia, providing an integrated clinical
                      research platform for research studies.The DEMREG study
                      longitudinally collects demographic, clinical, genetic,
                      biological, and imaging data, along with risk factors and
                      treatment information from real-world settings.
                      Comprehensive clinical assessments are conducted yearly.
                      This extensive resource enables researchers to investigate
                      current diagnostic and treatment practices and explore the
                      complex relationships between risk factors and outcomes. The
                      registry is now active across 22 sites in Germany, all
                      members of the the German Memory Clinic Network (DNG), with
                      more than 500 patients recruited to date, and is expected to
                      include up to 1.000 patients annually.The DEMREG study
                      represents a large nationally harmonized cohort of detailed
                      real-world clinical and biological data from patients with
                      cognitive impairment and dementia, enabling insights into
                      long-term dynamics and treatment responses. This
                      infrastructure has the potential to foster collaborative
                      research and roll out healthcare innovations across
                      different settings in Germany. In this context, a substudy
                      will soon be conducted to evaluate long-term safety and
                      efficacy measures of the new monoclonal antibodies targeting
                      amyloid plaques in a clinical setting.The protocol is
                      registered at German Clinical Trials Register
                      (DRKS00027547), Date of Registration: 01.04.2022.},
      keywords     = {Biomarkers (Other) / Dementia (Other) / Mild cognitive
                      impairment (Other) / Natural history (Other) /
                      Neurodegeneration (Other) / Registry (Other) / Treatment
                      (Other)},
      cin          = {AG Flöel / AG Düzel / Clinical Research (Munich) / AG
                      Jessen},
      ddc          = {610},
      cid          = {I:(DE-2719)5000081 / I:(DE-2719)5000006 /
                      I:(DE-2719)1111015 / I:(DE-2719)1011102},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41146293},
      pmc          = {pmc:PMC12560544},
      doi          = {10.1186/s42466-025-00433-9},
      url          = {https://pub.dzne.de/record/281831},
}