TY  - JOUR
AU  - Neubauer, Antonia
AU  - Weissenbrunner, Doris
AU  - Pekrun, Susanna
AU  - Roeber, Sigrun
AU  - Ruf, Viktoria
AU  - Feyen, Paul
AU  - Strübing, Felix L
AU  - Herms, Jochen
TI  - Alpha-synuclein deposition patterns in Alzheimer's disease: association with cortical amyloid beta and variable tau load.
JO  - Acta neuropathologica
VL  - 150
IS  - 1
SN  - 0001-6322
CY  - Heidelberg
PB  - Springer
M1  - DZNE-2025-01219
SP  - 46
PY  - 2025
AB  - Alpha-synuclein (α-syn) deposits are common in around half of the Alzheimer's disease (AD) cases. While direct and indirect protein interactions are suggested, the relationships between different protein aggregates remain poorly understood. Here, we aimed to characterize α-syn, amyloid beta (Aβ), and tau load distributions of AD patients. Protein deposits were automatically quantified with random forest pixel classifiers in immunohistochemical stains of up to 28 brain regions in 72 brains with advanced AD neuropathological change. α-syn-negative cases were distinguished from amygdala predominant, brainstem predominant, and cortical α-syn-positive cases. Relationships with age, sex, and ApoE genotype were examined. α-syn co-pathology was detected in 60
KW  - Humans
KW  - Alzheimer Disease: pathology
KW  - Alzheimer Disease: metabolism
KW  - Alzheimer Disease: genetics
KW  - Female
KW  - Male
KW  - alpha-Synuclein: metabolism
KW  - tau Proteins: metabolism
KW  - Amyloid beta-Peptides: metabolism
KW  - Aged
KW  - Aged, 80 and over
KW  - Cerebral Cortex: metabolism
KW  - Cerebral Cortex: pathology
KW  - Middle Aged
KW  - Brain: pathology
KW  - Brain: metabolism
KW  - Apolipoproteins E: genetics
KW  - Alpha-synuclein (Other)
KW  - Alzheimer’s disease (Other)
KW  - Immunohistochemistry (Other)
KW  - Lewy body disease (Other)
KW  - Mixed pathology (Other)
KW  - Quantitative neuropathology (Other)
KW  - alpha-Synuclein (NLM Chemicals)
KW  - tau Proteins (NLM Chemicals)
KW  - Amyloid beta-Peptides (NLM Chemicals)
KW  - Apolipoproteins E (NLM Chemicals)
KW  - MAPT protein, human (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:41165827
DO  - DOI:10.1007/s00401-025-02952-w
UR  - https://pub.dzne.de/record/281839
ER  -