TY  - JOUR
AU  - Beschorner, Natalie
AU  - Xu, Ying
AU  - Jucker, Mathias
AU  - Ruiz-Riquelme, Alejandro
TI  - Amyloid‐β Seeds in Alzheimer's Disease: Research Challenges and Implications
JO  - Journal of neurochemistry
VL  - 169
IS  - 11
SN  - 0022-3042
CY  - Oxford
PB  - Wiley-Blackwell
M1  - DZNE-2025-01224
SP  - e70267
PY  - 2025
AB  -  The amyloid cascade hypothesis, proposed over 30 years ago, places amyloid-β (Aβ) at the center of Alzheimer's disease (AD) pathogenesis. Though controversial, recent clinical successes with Aβ-targeting therapies have reinforced its importance. However, these treatments have shown only modest clinical benefits in line with a two-stage AD progression: an early phase driven by Aβ-seed and a later phase that progresses at least partly independently of Aβ. Evidence of Aβ seed transmission in humans raises both therapeutic potential and biosafety concerns. This review explores current understanding of Aβ seeds, including challenges in studying such seeds, model systems to study Aβ seeds, and biosafety issues when working with Aβ seeds.
KW  - Alzheimer Disease: metabolism
KW  - Alzheimer Disease: pathology
KW  - Humans
KW  - Amyloid beta-Peptides: metabolism
KW  - Animals
LB  - PUB:(DE-HGF)16
C6  - pmid:41185432
C2  - pmc:PMC12583922
DO  - DOI:10.1111/jnc.70267
UR  - https://pub.dzne.de/record/281845
ER  -