% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Beschorner:281845,
      author       = {Beschorner, Natalie and Xu, Ying and Jucker, Mathias and
                      Ruiz-Riquelme, Alejandro},
      title        = {{A}myloid‐β {S}eeds in {A}lzheimer's {D}isease:
                      {R}esearch {C}hallenges and {I}mplications},
      journal      = {Journal of neurochemistry},
      volume       = {169},
      number       = {11},
      issn         = {0022-3042},
      address      = {Oxford},
      publisher    = {Wiley-Blackwell},
      reportid     = {DZNE-2025-01224},
      pages        = {e70267},
      year         = {2025},
      abstract     = {The amyloid cascade hypothesis, proposed over 30 years ago,
                      places amyloid-β (Aβ) at the center of Alzheimer's disease
                      (AD) pathogenesis. Though controversial, recent clinical
                      successes with Aβ-targeting therapies have reinforced its
                      importance. However, these treatments have shown only modest
                      clinical benefits in line with a two-stage AD progression:
                      an early phase driven by Aβ-seed and a later phase that
                      progresses at least partly independently of Aβ. Evidence of
                      Aβ seed transmission in humans raises both therapeutic
                      potential and biosafety concerns. This review explores
                      current understanding of Aβ seeds, including challenges in
                      studying such seeds, model systems to study Aβ seeds, and
                      biosafety issues when working with Aβ seeds.},
      subtyp        = {Review Article},
      keywords     = {Alzheimer Disease: metabolism / Alzheimer Disease:
                      pathology / Humans / Amyloid beta-Peptides: metabolism /
                      Animals},
      cin          = {AG Petzold / AG Jucker},
      ddc          = {610},
      cid          = {I:(DE-2719)1013020 / I:(DE-2719)1210001},
      pnm          = {353 - Clinical and Health Care Research (POF4-353) / 352 -
                      Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-353 / G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41185432},
      pmc          = {pmc:PMC12583922},
      doi          = {10.1111/jnc.70267},
      url          = {https://pub.dzne.de/record/281845},
}