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@ARTICLE{Beschorner:281845,
      author       = {Beschorner, Natalie and Xu, Ying and Jucker, Mathias and
                      Ruiz-Riquelme, Alejandro},
      title        = {{A}myloid‐β {S}eeds in {A}lzheimer's {D}isease:
                      {R}esearch {C}hallenges and {I}mplications},
      journal      = {Journal of neurochemistry},
      volume       = {169},
      number       = {11},
      issn         = {0022-3042},
      address      = {Oxford},
      publisher    = {Wiley-Blackwell},
      reportid     = {DZNE-2025-01224},
      pages        = {e70267},
      year         = {2025},
      abstract     = {The amyloid cascade hypothesis, proposed over 30 years
                      ago, places amyloid-β (Aβ) at the center of Alzheimer's
                      disease (AD) pathogenesis. Though controversial, recent
                      clinical successes with Aβ-targeting therapies have
                      reinforced its importance. However, these treatments have
                      shown only modest clinical benefits in line with a two-stage
                      AD progression: an early phase driven by Aβ-seed and a
                      later phase that progresses at least partly independently of
                      Aβ. Evidence of Aβ seed transmission in humans raises both
                      therapeutic potential and biosafety concerns. This review
                      explores current understanding of Aβ seeds, including
                      challenges in studying such seeds, model systems to study
                      Aβ seeds, and biosafety issues when working with Aβ
                      seeds.},
      subtyp        = {Review Article},
      cin          = {AG Petzold / AG Jucker},
      ddc          = {610},
      cid          = {I:(DE-2719)1013020 / I:(DE-2719)1210001},
      pnm          = {353 - Clinical and Health Care Research (POF4-353) / 352 -
                      Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-353 / G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)16},
      doi          = {10.1111/jnc.70267},
      url          = {https://pub.dzne.de/record/281845},
}