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000281852 0247_ $$2ISSN$$a1546-1726
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000281852 1001_ $$0P:(DE-HGF)0$$aHirschler, Lydiane$$b0
000281852 245__ $$aRegion-specific drivers of CSF mobility measured with MRI in humans.
000281852 260__ $$aNew York, NY$$bNature America$$c2025
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000281852 520__ $$aMany neurological diseases are characterized by the accumulation of toxic proteins in the brain. This accumulation has been associated with improper clearance from the parenchyma. Recent discoveries highlighted perivascular spaces, which are cerebrospinal fluid (CSF)-filled spaces, as the channels of brain clearance. The forces driving CSF mobility within perivascular spaces are still debated. Here we present a noninvasive, CSF-specific magnetic resonance imaging technique (CSF-Selective T2-prepared REadout with Acceleration and Mobility-encoding) that enables detailed in vivo measurement of CSF mobility in humans, down to the level of perivascular spaces located around penetrating vessels, which is close to protein production sites. We find region-specific drivers of CSF mobility and demonstrate that CSF mobility can be increased by entraining vasomotion. Furthermore, we find region-specific CSF mobility alterations in patients with cerebral amyloid angiopathy, a brain disorder associated with clearance impairment. The availability of this technique opens up avenues to investigate the impact of CSF-mediated clearance in neurodegeneration and sleep.
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000281852 650_2 $$2MeSH$$aHumans
000281852 650_2 $$2MeSH$$aMagnetic Resonance Imaging: methods
000281852 650_2 $$2MeSH$$aCerebrospinal Fluid: diagnostic imaging
000281852 650_2 $$2MeSH$$aCerebrospinal Fluid: physiology
000281852 650_2 $$2MeSH$$aCerebrospinal Fluid: metabolism
000281852 650_2 $$2MeSH$$aMale
000281852 650_2 $$2MeSH$$aFemale
000281852 650_2 $$2MeSH$$aBrain: diagnostic imaging
000281852 650_2 $$2MeSH$$aAdult
000281852 650_2 $$2MeSH$$aGlymphatic System: diagnostic imaging
000281852 650_2 $$2MeSH$$aMiddle Aged
000281852 7001_ $$00009-0007-5491-5379$$aRunderkamp, Bobby A$$b1
000281852 7001_ $$0P:(DE-2719)9001544$$aDecker, Andreas$$b2$$udzne
000281852 7001_ $$00000-0002-3408-9379$$avan Harten, Thijs W$$b3
000281852 7001_ $$0P:(DE-HGF)0$$aScheyhing, Paul$$b4
000281852 7001_ $$0P:(DE-2719)2812222$$aEhses, Philipp$$b5$$udzne
000281852 7001_ $$aPetitclerc, Léonie$$b6
000281852 7001_ $$0P:(DE-HGF)0$$aLayer, Julia$$b7
000281852 7001_ $$0P:(DE-2719)2810559$$aPracht, Eberhard$$b8$$udzne
000281852 7001_ $$aCoolen, Bram F$$b9
000281852 7001_ $$00000-0003-3223-9721$$avan der Zwaag, Wietske$$b10
000281852 7001_ $$0P:(DE-2719)2810538$$aStöcker, Tony$$b11
000281852 7001_ $$aVollmuth, Philipp$$b12
000281852 7001_ $$0P:(DE-2719)9001705$$aPaech, Daniel$$b13$$udzne
000281852 7001_ $$0P:(DE-2719)9002732$$aEffland, Alexander$$b14$$udzne
000281852 7001_ $$avan Walderveen, Marianne A A$$b15
000281852 7001_ $$0P:(DE-2719)9001861$$aRadbruch, Alexander$$b16$$udzne
000281852 7001_ $$avan Buchem, Mark A$$b17
000281852 7001_ $$0P:(DE-2719)2810273$$aPetzold, Gabor C$$b18
000281852 7001_ $$00000-0002-7957-8643$$avan Veluw, Susanne J$$b19
000281852 7001_ $$aCaan, Matthan W A$$b20
000281852 7001_ $$0P:(DE-2719)9001745$$aDeike-Hofmann, Katerina$$b21$$eLast author
000281852 7001_ $$00000-0001-7034-8959$$avan Osch, Matthias J P$$b22
000281852 773__ $$0PERI:(DE-600)1494955-6$$a10.1038/s41593-025-02073-3$$gVol. 28, no. 11, p. 2392 - 2401$$n11$$p2392 - 2401$$tNature neuroscience$$v28$$x1097-6256$$y2025
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