TY  - JOUR
AU  - Hirschler, Lydiane
AU  - Runderkamp, Bobby A
AU  - Decker, Andreas
AU  - van Harten, Thijs W
AU  - Scheyhing, Paul
AU  - Ehses, Philipp
AU  - Petitclerc, Léonie
AU  - Layer, Julia
AU  - Pracht, Eberhard
AU  - Coolen, Bram F
AU  - van der Zwaag, Wietske
AU  - Stöcker, Tony
AU  - Vollmuth, Philipp
AU  - Paech, Daniel
AU  - Effland, Alexander
AU  - van Walderveen, Marianne A A
AU  - Radbruch, Alexander
AU  - van Buchem, Mark A
AU  - Petzold, Gabor C
AU  - van Veluw, Susanne J
AU  - Caan, Matthan W A
AU  - Deike-Hofmann, Katerina
AU  - van Osch, Matthias J P
TI  - Region-specific drivers of CSF mobility measured with MRI in humans.
JO  - Nature neuroscience
VL  - 28
IS  - 11
SN  - 1097-6256
CY  - New York, NY
PB  - Nature America
M1  - DZNE-2025-01225
SP  - 2392 - 2401
PY  - 2025
AB  - Many neurological diseases are characterized by the accumulation of toxic proteins in the brain. This accumulation has been associated with improper clearance from the parenchyma. Recent discoveries highlighted perivascular spaces, which are cerebrospinal fluid (CSF)-filled spaces, as the channels of brain clearance. The forces driving CSF mobility within perivascular spaces are still debated. Here we present a noninvasive, CSF-specific magnetic resonance imaging technique (CSF-Selective T2-prepared REadout with Acceleration and Mobility-encoding) that enables detailed in vivo measurement of CSF mobility in humans, down to the level of perivascular spaces located around penetrating vessels, which is close to protein production sites. We find region-specific drivers of CSF mobility and demonstrate that CSF mobility can be increased by entraining vasomotion. Furthermore, we find region-specific CSF mobility alterations in patients with cerebral amyloid angiopathy, a brain disorder associated with clearance impairment. The availability of this technique opens up avenues to investigate the impact of CSF-mediated clearance in neurodegeneration and sleep.
KW  - Humans
KW  - Magnetic Resonance Imaging: methods
KW  - Cerebrospinal Fluid: diagnostic imaging
KW  - Cerebrospinal Fluid: physiology
KW  - Cerebrospinal Fluid: metabolism
KW  - Male
KW  - Female
KW  - Brain: diagnostic imaging
KW  - Adult
KW  - Glymphatic System: diagnostic imaging
KW  - Middle Aged
LB  - PUB:(DE-HGF)16
C6  - pmid:41087750
DO  - DOI:10.1038/s41593-025-02073-3
UR  - https://pub.dzne.de/record/281852
ER  -