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@ARTICLE{Hirschler:281852,
      author       = {Hirschler, Lydiane and Runderkamp, Bobby A and Decker,
                      Andreas and van Harten, Thijs W and Scheyhing, Paul and
                      Ehses, Philipp and Petitclerc, Léonie and Layer, Julia and
                      Pracht, Eberhard and Coolen, Bram F and van der Zwaag,
                      Wietske and Stöcker, Tony and Vollmuth, Philipp and Paech,
                      Daniel and Effland, Alexander and van Walderveen, Marianne A
                      A and Radbruch, Alexander and van Buchem, Mark A and
                      Petzold, Gabor C and van Veluw, Susanne J and Caan, Matthan
                      W A and Deike-Hofmann, Katerina and van Osch, Matthias J P},
      title        = {{R}egion-specific drivers of {CSF} mobility measured with
                      {MRI} in humans.},
      journal      = {Nature neuroscience},
      volume       = {28},
      number       = {11},
      issn         = {1097-6256},
      address      = {New York, NY},
      publisher    = {Nature America},
      reportid     = {DZNE-2025-01225},
      pages        = {2392 - 2401},
      year         = {2025},
      abstract     = {Many neurological diseases are characterized by the
                      accumulation of toxic proteins in the brain. This
                      accumulation has been associated with improper clearance
                      from the parenchyma. Recent discoveries highlighted
                      perivascular spaces, which are cerebrospinal fluid
                      (CSF)-filled spaces, as the channels of brain clearance. The
                      forces driving CSF mobility within perivascular spaces are
                      still debated. Here we present a noninvasive, CSF-specific
                      magnetic resonance imaging technique (CSF-Selective
                      T2-prepared REadout with Acceleration and Mobility-encoding)
                      that enables detailed in vivo measurement of CSF mobility in
                      humans, down to the level of perivascular spaces located
                      around penetrating vessels, which is close to protein
                      production sites. We find region-specific drivers of CSF
                      mobility and demonstrate that CSF mobility can be increased
                      by entraining vasomotion. Furthermore, we find
                      region-specific CSF mobility alterations in patients with
                      cerebral amyloid angiopathy, a brain disorder associated
                      with clearance impairment. The availability of this
                      technique opens up avenues to investigate the impact of
                      CSF-mediated clearance in neurodegeneration and sleep.},
      keywords     = {Humans / Magnetic Resonance Imaging: methods /
                      Cerebrospinal Fluid: diagnostic imaging / Cerebrospinal
                      Fluid: physiology / Cerebrospinal Fluid: metabolism / Male /
                      Female / Brain: diagnostic imaging / Adult / Glymphatic
                      System: diagnostic imaging / Middle Aged},
      cin          = {AG Radbruch / AG Stöcker / AG Petzold},
      ddc          = {610},
      cid          = {I:(DE-2719)5000075 / I:(DE-2719)1013026 /
                      I:(DE-2719)1013020},
      pnm          = {353 - Clinical and Health Care Research (POF4-353) / 354 -
                      Disease Prevention and Healthy Aging (POF4-354)},
      pid          = {G:(DE-HGF)POF4-353 / G:(DE-HGF)POF4-354},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41087750},
      doi          = {10.1038/s41593-025-02073-3},
      url          = {https://pub.dzne.de/record/281852},
}