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000281854 037__ $$aDZNE-2025-01227
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000281854 1001_ $$0P:(DE-2719)9002356$$aFischer, Larissa$$b0$$eFirst author
000281854 245__ $$aLongitudinal functional connectivity during rest and task is differentially related to Alzheimer's pathology and episodic memory in older adults.
000281854 260__ $$a[London]$$bSpringer Nature$$c2025
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000281854 520__ $$aChanges in functional connectivity (FC) strength involving the medial temporal lobe (MTL) and posteromedial cortex (PMC) are related to early Alzheimer's pathology and alterations in episodic memory performance in cognitively unimpaired older adults, but their dynamics remain unclear. We examined how longitudinal changes in FC involving MTL and PMC during resting-state, episodic memory encoding, and retrieval relate to subsequent amyloid- and tau-PET burden, longitudinal episodic memory performance, and the APOE4 genotype in 152 cognitively unimpaired older adults from the PREVENT-AD cohort. We found APOE4- and fMRI paradigm-dependent associations of change in FC strength with pathology burden and change in episodic memory performance. Decreasing FC over time, or 'hypoconnectivity', within PMC during rest in APOE4 carriers and during retrieval in APOE4 non-carriers was related to more amyloid and tau, respectively. Conversely, increasing FC over time, or 'hyperconnectivity', within MTL during encoding in APOE4 carriers and between MTL and PMC during retrieval independent of APOE4 status was related to more tau. Further, increasing FC between MTL and PMC during rest, unlike during encoding, was beneficial for episodic memory. Our study highlights that pathology-related episodic memory network changes manifest differently during rest and task and have differential implications for episodic memory trajectories.
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000281854 650_7 $$2Other$$aAPOE4
000281854 650_7 $$2Other$$aAging
000281854 650_7 $$2Other$$aAlzheimer’s disease
000281854 650_7 $$2Other$$aEpisodic memory
000281854 650_7 $$2Other$$aFunctional connectivity
000281854 650_7 $$2Other$$afMRI
000281854 650_7 $$2NLM Chemicals$$aApolipoprotein E4
000281854 650_7 $$2NLM Chemicals$$atau Proteins
000281854 650_2 $$2MeSH$$aHumans
000281854 650_2 $$2MeSH$$aMemory, Episodic
000281854 650_2 $$2MeSH$$aAlzheimer Disease: physiopathology
000281854 650_2 $$2MeSH$$aAlzheimer Disease: pathology
000281854 650_2 $$2MeSH$$aAlzheimer Disease: diagnostic imaging
000281854 650_2 $$2MeSH$$aAlzheimer Disease: metabolism
000281854 650_2 $$2MeSH$$aAged
000281854 650_2 $$2MeSH$$aFemale
000281854 650_2 $$2MeSH$$aMale
000281854 650_2 $$2MeSH$$aMagnetic Resonance Imaging
000281854 650_2 $$2MeSH$$aApolipoprotein E4: genetics
000281854 650_2 $$2MeSH$$aRest: physiology
000281854 650_2 $$2MeSH$$aTemporal Lobe: physiopathology
000281854 650_2 $$2MeSH$$aTemporal Lobe: diagnostic imaging
000281854 650_2 $$2MeSH$$aTemporal Lobe: pathology
000281854 650_2 $$2MeSH$$atau Proteins: metabolism
000281854 650_2 $$2MeSH$$aLongitudinal Studies
000281854 650_2 $$2MeSH$$aAged, 80 and over
000281854 650_2 $$2MeSH$$aPositron-Emission Tomography
000281854 650_2 $$2MeSH$$aMiddle Aged
000281854 7001_ $$00000-0002-6702-3851$$aAdams, Jenna N$$b1
000281854 7001_ $$0P:(DE-2719)9002180$$aMolloy, Eóin N.$$b2
000281854 7001_ $$aTremblay-Mercier, Jennifer$$b3
000281854 7001_ $$aRemz, Jordana$$b4
000281854 7001_ $$00000-0001-5218-3337$$aBinette, Alexa Pichet$$b5
000281854 7001_ $$aRajah, M Natasha$$b6
000281854 7001_ $$00000-0003-2338-0467$$aVilleneuve, Sylvia$$b7
000281854 7001_ $$0P:(DE-2719)2811815$$aMaass, Anne$$b8$$eLast author
000281854 7001_ $$aGroup, PREVENT-AD Research$$b9$$eCollaboration Author
000281854 7001_ $$aPoirier, Judes$$b10$$eContributor
000281854 7001_ $$aBreitner, John C S$$b11$$eContributor
000281854 7001_ $$aBadawy, Mohamed$$b12$$eContributor
000281854 7001_ $$aBaillet, Sylvain$$b13$$eContributor
000281854 7001_ $$aBaril, Andrée-Ann$$b14$$eContributor
000281854 7001_ $$aBellec, Pierre$$b15$$eContributor
000281854 7001_ $$aBohbot, Véronique$$b16$$eContributor
000281854 7001_ $$aBzdok, Danilo$$b17$$eContributor
000281854 7001_ $$aChakravarty, Mallar$$b18$$eContributor
000281854 7001_ $$aCollins, D Louis$$b19$$eContributor
000281854 7001_ $$aDadar, Mahsa$$b20$$eContributor
000281854 7001_ $$aDucharme, Simon$$b21$$eContributor
000281854 7001_ $$aEvans, Alan$$b22$$eContributor
000281854 7001_ $$aGauthier, Claudine$$b23$$eContributor
000281854 7001_ $$aGeddes, Maiya R$$b24$$eContributor
000281854 7001_ $$aHoge, Rick$$b25$$eContributor
000281854 7001_ $$aIturia-Medina, Yasser$$b26$$eContributor
000281854 7001_ $$aMulthaup, Gerhard$$b27$$eContributor
000281854 7001_ $$aMünter, Lisa-Marie$$b28$$eContributor
000281854 7001_ $$aRajah, M Natasha$$b29$$eContributor
000281854 7001_ $$aRosa-Neto, Pedro$$b30$$eContributor
000281854 7001_ $$aSchmitz, Taylor$$b31$$eContributor
000281854 7001_ $$aSoucy, Jean-Paul$$b32$$eContributor
000281854 7001_ $$aSpreng, Nathan$$b33$$eContributor
000281854 7001_ $$aTardif, Christine$$b34$$eContributor
000281854 7001_ $$aVachon-Presseau, Etienne$$b35$$eContributor
000281854 7001_ $$aBocti, Christian$$b36$$eContributor
000281854 7001_ $$aDescoteaux, Maxime$$b37$$eContributor
000281854 7001_ $$aLaforce, Robert$$b38$$eContributor
000281854 7001_ $$aBinette, Alexa Pichet$$b39$$eContributor
000281854 773__ $$0PERI:(DE-600)2615211-3$$a10.1038/s41598-025-21596-0$$gVol. 15, no. 1, p. 38499$$n1$$p38499$$tScientific reports$$v15$$x2045-2322$$y2025
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