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@ARTICLE{Fischer:281854,
      author       = {Fischer, Larissa and Adams, Jenna N and Molloy, Eóin N.
                      and Tremblay-Mercier, Jennifer and Remz, Jordana and
                      Binette, Alexa Pichet and Rajah, M Natasha and Villeneuve,
                      Sylvia and Maass, Anne},
      collaboration = {Group, PREVENT-AD Research},
      othercontributors = {Poirier, Judes and Breitner, John C S and Badawy, Mohamed
                          and Baillet, Sylvain and Baril, Andrée-Ann and Bellec,
                          Pierre and Bohbot, Véronique and Bzdok, Danilo and
                          Chakravarty, Mallar and Collins, D Louis and Dadar, Mahsa
                          and Ducharme, Simon and Evans, Alan and Gauthier, Claudine
                          and Geddes, Maiya R and Hoge, Rick and Ituria-Medina, Yasser
                          and Multhaup, Gerhard and Münter, Lisa-Marie and Rajah, M
                          Natasha and Rosa-Neto, Pedro and Schmitz, Taylor and Soucy,
                          Jean-Paul and Spreng, Nathan and Tardif, Christine and
                          Vachon-Presseau, Etienne and Bocti, Christian and
                          Descoteaux, Maxime and Laforce, Robert and Binette, Alexa
                          Pichet},
      title        = {{L}ongitudinal functional connectivity during rest and task
                      is differentially related to {A}lzheimer's pathology and
                      episodic memory in older adults.},
      journal      = {Scientific reports},
      volume       = {15},
      number       = {1},
      issn         = {2045-2322},
      address      = {[London]},
      publisher    = {Springer Nature},
      reportid     = {DZNE-2025-01227},
      pages        = {38499},
      year         = {2025},
      abstract     = {Changes in functional connectivity (FC) strength involving
                      the medial temporal lobe (MTL) and posteromedial cortex
                      (PMC) are related to early Alzheimer's pathology and
                      alterations in episodic memory performance in cognitively
                      unimpaired older adults, but their dynamics remain unclear.
                      We examined how longitudinal changes in FC involving MTL and
                      PMC during resting-state, episodic memory encoding, and
                      retrieval relate to subsequent amyloid- and tau-PET burden,
                      longitudinal episodic memory performance, and the APOE4
                      genotype in 152 cognitively unimpaired older adults from the
                      PREVENT-AD cohort. We found APOE4- and fMRI
                      paradigm-dependent associations of change in FC strength
                      with pathology burden and change in episodic memory
                      performance. Decreasing FC over time, or 'hypoconnectivity',
                      within PMC during rest in APOE4 carriers and during
                      retrieval in APOE4 non-carriers was related to more amyloid
                      and tau, respectively. Conversely, increasing FC over time,
                      or 'hyperconnectivity', within MTL during encoding in APOE4
                      carriers and between MTL and PMC during retrieval
                      independent of APOE4 status was related to more tau.
                      Further, increasing FC between MTL and PMC during rest,
                      unlike during encoding, was beneficial for episodic memory.
                      Our study highlights that pathology-related episodic memory
                      network changes manifest differently during rest and task
                      and have differential implications for episodic memory
                      trajectories.},
      keywords     = {Humans / Memory, Episodic / Alzheimer Disease:
                      physiopathology / Alzheimer Disease: pathology / Alzheimer
                      Disease: diagnostic imaging / Alzheimer Disease: metabolism
                      / Aged / Female / Male / Magnetic Resonance Imaging /
                      Apolipoprotein E4: genetics / Rest: physiology / Temporal
                      Lobe: physiopathology / Temporal Lobe: diagnostic imaging /
                      Temporal Lobe: pathology / tau Proteins: metabolism /
                      Longitudinal Studies / Aged, 80 and over / Positron-Emission
                      Tomography / Middle Aged / APOE4 (Other) / Aging (Other) /
                      Alzheimer’s disease (Other) / Episodic memory (Other) /
                      Functional connectivity (Other) / fMRI (Other) /
                      Apolipoprotein E4 (NLM Chemicals) / tau Proteins (NLM
                      Chemicals)},
      cin          = {AG Maaß},
      ddc          = {600},
      cid          = {I:(DE-2719)1311001},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41188354},
      doi          = {10.1038/s41598-025-21596-0},
      url          = {https://pub.dzne.de/record/281854},
}